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FLASH GENE

Symbol

LRP1B

contributors: mct/npt - updated : 08-06-2021

HGNC name	low density lipoprotein-related protein 1B (deleted in tumors)
HGNC id	6693

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	2q22.1      Physical location : 140.988.995 - 142.889.270
Synonym name	low-density lipoprotein receptor-related protein-deleted in tumor
Synonym symbol(s)	LRPDIT, LRP-DIT

DNA

TYPE	functioning gene
STRUCTURE	1901.04 kb     91 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_018557 91 - 15850 NP_061027 515.4 4599 - 2019 31054778

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth           salivary gland         Endocrine thyroid         Nervous brain

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to murine Lrp1b

intraspecies

homolog to LRP1

Homologene

FAMILY

low density lipoprotein receptor gene family ( LDLR)

CATEGORY

receptor

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	putative endocytic receptor
	transducer of extracellular signals, and may be involved in signal transduction (Shiroshima 2009)
	suppressive roles of LRP1B in the progression of colon cancer
	LRP1B plays a pivotal role in maintaining lipid homeostasis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	binding of PICK1 inhibits phosphorylation of LRP1B, but does not affect LRP1 phosphorylation (Shiroshima 2009)
	HSF1 directly regulated the transcription of LRP1B and was involved in LRP1B-mediated lipid metabolism in hepatocellular carcinoma (HCC)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       loss of function in urothelial cancer, frequently inactivated in non small-cell lung carcinoma tumoral       loss of function results in changes to the tumor environment that confer cancer cells an increased growth and invasive capacity tumoral     --over   in Hepatocellular Carcinoma

Susceptibility

to obesity to idiopathic acquired pure red cell aplasia (PRCA)

Variant & Polymorphism SNP	single nucleotide polymorphism (rs431809) in intron 4, significantly correlated with both body mass index (BMI) and waist-hip-ratio (WHR)
	LRP1B mutations may be associated with acquired PRCA

Candidate gene
Marker	biomarker for thyroid cancer exhibiting differences in the correlation coefficients between benign and malignant samples that indicate its discriminatory power
	Nuclear LRP1B was significantly associated with poor patient prognosis in breast cancer cells and nuclear expression of LRP1B intracellular domain increased NEAT1 expression
Therapy target
	System Type Disorder Pubmed obesity     Genetic and epigenetic crosstalk of LRP1B gene may be implicated in the prevention and therapeutic approach to childhood obesity cancer digestive colon restoring the function of LRP1B would be a promising strategy for the treatment of colon cancer

ANIMAL & CELL MODELS