motifs/domains
| thirty one copies of the ligand binding domain, equivalent to the classical LDL receptor motif, cysteine rich, arranged in four clusters |
|
sixteen growth factor repeats |
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one EGF-like motif |
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a transmembrane segment (1TM) |
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a short cytoplasmic tail, with internalization signals, common 600 RD precursor of 500 and 85kD chains |
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two NPXY motifs in the intracellular domain (ICD) serve as docking sites for several cytoplasmic adaptor proteins, and interact with signaling proteins  , |
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FXNPXY63 motif not only governs cellular localization of the receptor but also exerts multiple functional effects on signalling pathways involved in cell growth regulation |
| basic FUNCTION
| macroglobulin, alpha-2-receptor (proteinase complexes receptor) |
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multiligand receptor for beta lipoprotein, binding chylomicron remnants, beta VLDL, lipoprotein lipase, lactoferrin, proteinase inhibitors |
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fibronectin catabolic receptor involved in the phagocytosis of apoptotic cells in mammals |
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involved in the processes of cell migration and invasion, as well as in the regulation of growth factor homeostasis |
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may be involved in cell migration and invasion of the retinal pigment epithelial (RPE) cells |
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controls signaling pathways involved in cholesterol storage and fatty acid synthesis during adipocyte differentiation |
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required for lipolysis and stimulates fatty acid synthesis independently of the noradrenergic pathway, through inhibition of GSK3B and its previously unknown target acetyl-CoA carboxylase |
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essential for the maintenance of vascular wall integrity, particularly in the presence of high plasma lipid levels |
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integrator of adipogenic differentiation and fat storage signals |
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playing an unique role in endocytosis of a coagulation protein trafficked to alpha-granules and not destined for lysosomal degradation |
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may facilitate the development and growth of cancer metastases |
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controls both the surface, and biosynthetic, trafficking of PRNP in neurons |
