Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol LRMP contributors: mct/npt - updated : 16-05-2008
HGNC name lymphoid-restricted membrane protein
HGNC id 6690
Location 12p12.1      Physical location : 25.205.240 - 25.261.268
Synonym name protein Jaw1
Synonym symbol(s) EVI79, JAW1
DNA
TYPE functioning gene
STRUCTURE 56.00 kb     21 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
SIAT8A 12p12.3-p12.2 sialyltransferase 8A (alpha-N-acetylneuraminate: alpha-2,8-sialyltransferase, GD3 synthase) KIAA0528 12p12.2 sialyltransferase 8A (alpha-N-acetylneuraminate: alpha-2,8-sialyltransferase, GD3 synthase) EKI1 12p12.3 sialyltransferase 8A (alpha-N-acetylneuraminate: alpha-2,8-sialyltransferase, GD3 synthase) SOX5 12p12.1 SRY (sex determining region Y)-box 5 FLJ32894 12p12.1 hypothetical protein FLJ32894 LOC387846 12 LOC387846 BCAT1 12pter-q12 branched chain aminotransferase 1, cytosolic LOC121153 12p12.1 similar to Brain protein I3 (pRGR2) LOC387847 12 LOC387847 LRMP 12p12.1 lymphoid-restricted membrane protein LAS1 LOC144363 12p12.1 hypothetical protein LOC144363 KRAS2 12p12.1 v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog FLJ36004 12p12.1 hypothetical protein FLJ36004 LOC283347 12p12.1 similar to thymine-DNA glycosylase C12orf2 12p12.3 chromosome 12 open reading frame 2 BHLHB3 12p12.1-p11.23 basic helix-loop-helix domain containing, class B, 3 LOC387848 12 LOC387848 SSPN 12p11.2 sarcospan (Kras oncogene-associated gene) ITPR2 12p11 inositol 1,4,5-triphosphate receptor, type 2 LOC341370 12p12.1 similar to Dag1-prov protein FLJ10637 12p12.1 hypothetical protein FLJ10637 DKFZP564O1863 TM7SF3 12q11.2-q12 transmembrane 7 superfamily member 3 SURB7 12p12.3 SRB7 suppressor of RNA polymerase B homolog (yeast) LOC341371 12p12.1 hypothetical LOC341371 STK38L 12p12.3-p11.22 serine/threonine kinase 38 like ARNTL2 12p11.23-p11.22 aryl hydrocarbon receptor nuclear translocator-like 2 LOC341346 12p12.1 similar to hypothetical protein PPFIBP1 12q14.3 PTPRF interacting protein, binding protein 1 (liprin beta 1) LOC387849 12 similar to RIKEN cDNA 2210417D09 MRPS35 12p11 mitochondrial ribosomal protein S35
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
21 - 2826 - 499 - Manenti (2006)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen    
 thymus    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticprogenitor cell
Lymphoid/ImmuneB cell
Lymphoid/ImmuneT cell
cell lineage
  • B cell lineage
  • T cell lineage
  • cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal cytosolic domain
  • a coiled-coil domain
  • a transmembrane region
  • a C terminal membrane anchor with a conserved lumenal tail region, 71 AAs, which contain a hydrophobic membrane spanning region, are sufficient to target a heterologous protein to the ER
  • isoforms Precursor cleavage of a C terminal peptide
    HOMOLOGY
    interspecies ortholog to murine Lrmp
    homolog to rattus Rn.54706
    Homologene
    FAMILY
    CATEGORY unknown/unspecified , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    text
  • localized to the cytoplasmic face of the endoplasmic reticulum
  • single-pass type IV membrane protein
  • basic FUNCTION unknown
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text hemocytes development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in diffuse large B-cell lymphomas of 'germinal centre' subtype
    Susceptibility to lung cancer
    Variant & Polymorphism other V141L polymorphism is associated with survival of lung cancer patients
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS