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FLASH GENE

Symbol

LRIG2

contributors: mct - updated : 16-03-2016

HGNC name	leucine-rich repeats and immunoglobulin-like domains 2
HGNC id	20889

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	UFS2 urofacial syndrome 2
Location	1p13.2      Physical location : 113.615.830 - 113.667.342
Synonym name	KIAA0806 gene product
Synonym symbol(s)	KIAA0806, LIG-2, LIG2

DNA

TYPE	functioning gene
STRUCTURE	51.51 kb     18 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014813 18 - 4015 NP_055628 132 1065 - 2004 15145052

EXPRESSION

Type

widely

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive stomach       predominantly Homo sapiens Adult NM_014813 Endocrine adrenal gland       predominantly Homo sapiens Adult NM_014813 Nervous brain       highly Homo sapiens Adult NM_014813 Reproductive female system ovary     predominantly Homo sapiens Adult NM_014813   female system uterus     predominantly Homo sapiens Adult NM_014813   male system prostate     highly Homo sapiens Fetal NM_014813 Respiratory lung       highly Homo sapiens Fetal NM_014813 Skin/Tegument skin       predominantly Homo sapiens Adult NM_014813 Urinary kidney       predominantly Homo sapiens Adult NM_014813

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular smooth     moderately Homo sapiens Adult NM_014813

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	liver moderately
	in stomach, and fetal brain 3)

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a signal peptide
	three ig-like C2-type (immunoglobulin-like) domains
	an extracellular part containing 15 LRR (leucine-rich) repeats
	a transmembrane domain, and a cytoplasmic tail

HOMOLOGY

interspecies	homolog to Drosophila trn
	homolog to C.elegans T21D12.9c

intraspecies

homolog to LRIG1

Homologene

FAMILY

CATEGORY

regulatory , RNA associated

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm
	intracellular,nucleus
text	type I membrane protein
	mostly localized at the nucleus of the pituitary adenoma cells

basic FUNCTION	involved in the translational initiation
	modulates cell turnover and adhesion in neural support cells via altered growth-factor signaling
	might have a function different from that of LRIG1, and possibly contributing to the etiology of oligodendroglioma
	may play an important role in pituitary adenoma invasiveness
	possible role for LRIG1 and LRIG2 proteins in meningioma pathogenesis
	required for normal lower-urinary-tract innervation and/or neural function
	LRIG genes appear to act both redundantly and independently, with LRIG2 emerging as the most functionally distinct family member
	LRIG2 appears to function as a tumor promoter

CELLULAR PROCESS

protein, translation/synthesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

UFS2

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in invasive pituitary adenoma tumoral     --over   in squamous cell carcinoma of the uterine cervix, with low LRIG1 expression identified women with a very poor prognosis

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS