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FLASH GENE
Symbol LRGUK contributors: mct - updated : 22-03-2022
HGNC name leucine rich repeats and guanylate kinase domain containing
HGNC id 21964
Location 7q33      Physical location : 133.812.104 - 133.948.933
Synonym symbol(s) CFAP246, LRGUK1
DNA
TYPE functioning gene
STRUCTURE 155.14 kb     16 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
20 - 3126 - 825 - 2015 25781171
15 - 2625 - 621 - 2015 25781171
16 - 5827 - 1130 - 2015 25781171
16 - 5830 - 1131 - 2015 25781171
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 3 domains: an LRR, that is essential for binding to KLC3
  • a guanylate kinase (GUK)-like, that is essential for binding to HOOK2 and RIMBP3,
  • an unnamed domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • is required for multiple aspects of sperm assembly, including acrosome attachment, sperm head shaping and the initiation of the axoneme growth to form the core of the sperm tail
  • is a major determinant of microtubule structure within the male germ line
  • is a key component of a multiprotein complex with an essential role in microtubule dynamics within haploid male germ cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS