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FLASH GENE
Symbol LRG1 contributors: SGE/npt - updated : 04-02-2010
HGNC name leucine-rich alpha-2-glycoprotein 1
HGNC id 29480
Location 19p13.3      Physical location : 4.537.227 - 4.540.036
Synonym name leucine rich alpha 2 glycoprotein
Synonym symbol(s) LRG, HMFT1766, 2310031E04Rik, 1300008B03Rik
DNA
TYPE functioning gene
STRUCTURE 2.81 kb     2 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1780 - 347 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinerectum  
 liver    
 stomach    
Endocrinepancreas    
Nervousbrain    
Reproductivemale systemprostate   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • eight leucine-rich (LRR) repeats
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • LRR family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION extracellular
    text secreted in the plasma
    basic FUNCTION
  • novel marker for early neutrophilic granulocyte differentiation
  • may have a role in protein-protein interaction, signal transduction, cell adhesion, development
  • may be involved in implantation/decidualization (Gillot 2008)
  • first extracellular ligand for CYC1 that has been identified (Cummings 206)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other secretory type 1 acute-phase protein whose expression is up-regulated by the mediator of acute-phase response (Shirai 2009)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS