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FLASH GENE

Symbol

LRFN5

contributors: mlc/npt - updated : 28-02-2014

HGNC name	leucine rich repeat and fibronectin type III domain containing 5
HGNC id	20360

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	AUTS22 autism spectrum disorder, LRFN5 related
Location	14q21.2      Physical location : 42.076.763 - 42.373.750
Synonym name	chromosome 14 open reading frame 146
	synaptic adhesion-like molecules 5
	fibronectin type III, immunoglobulin and leucine rich repeat domains 8
Synonym symbol(s)	C14orf146, FLJ30803, SALM5, FIGLER8, DKFZp686G0210

DNA

TYPE	functioning gene
STRUCTURE	296.41 kb     6 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_152447 6 - 3747 NP_689660 - 719 - - 16828986

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       moderately   nerve       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective       predominantly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	seven leucine-rich repeats domain (LRR)
	a fibronectin type-III domain (Fn)
	an immunoglobulin-like domain (Ig-like)
	lack PDZ binding domain

conjugated

GlycoP

HOMOLOGY

interspecies	homolog to murine Lrfn5 (96,59 pc)
	homolog to rattus Lrfn5_predicted (96,24 pc)

Homologene

FAMILY

LRFN family

CATEGORY

adhesion

SUBCELLULAR LOCALIZATION	plasma membrane
text	type I membrane protein

basic FUNCTION	neuronal components with a role in the developing or mature vertebrate nervous system
	play critical roles in the formation and maintenance of the central nervous system
	its expression in nonneural and neural cells induces both excitatory and inhibitory presynaptic differentiation in contacting axons
	with LRFN4, may promote synapse formation through distinct mechanism
	expression of LRFN4, LRFN5 in nonneural and neural cells induces both excitatory and inhibitory presynaptic differentiation in contacting axons
	LRFN4, LRFN5 possess synaptogenic activity, inducing presynaptic differentiation in contacting axons

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

homomeric or heteromeric complexes in brain and heterologous cells

INTERACTION

DNA

binding

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

AUTS22

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS