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FLASH GENE
Symbol LRFN4 contributors: mct - updated : 09-06-2012
HGNC name leucine rich repeat and fibronectin type III domain containing 4
HGNC id 28456
Location 11q13.2      Physical location : 66.624.875 - 66.627.945
Synonym name
  • synaptic adhesion-like molecules 3
  • fibronectin type III, immunoglobulin and leucine rich repeat domains 6
  • Synonym symbol(s) MGC3103, SALM3, FIGLER6
    DNA
    TYPE functioning gene
    STRUCTURE 3.07 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2546 - 635 - 2006 16828986
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
    Reproductivemale systemprostate  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven leucine-rich repeats domain (LRR)
  • a fibronectin type-III domain (Fn)
  • an immunoglobulin-like domain (Ig-like)
  • C-terminal PDZ-binding domain (PDZ-BD), which interacts with DLG4, an abundant postsynaptic scaffolding protein , and is required for most aspects of neurite outgrowth
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Lrfn4 (96,85 pc)
    Homologene
    FAMILY
  • SALM family
  • Leucine-rich repeat and fibronectin type III domain-containing (LRFN) family
  • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I membrane protein
    basic FUNCTION
  • neuronal components with a role in the developing or mature vertebrate nervous system
  • play critical roles in the formation and maintenance of the central nervous system
  • its expression in nonneural and neural cells induces both excitatory and inhibitory presynaptic differentiation in contacting axons
  • possess synaptogenic activity, inducing presynaptic differentiation in contacting
  • with LRFN5, may promote synapse formation through distinct mechanism
  • expression of LRFN4, LRFN5 in nonneural and neural cells induces both excitatory and inhibitory presynaptic differentiation in contacting axons
  • neuronal-specific proteins that play essential roles in neurite outgrowth and synapse formation
  • its signaling plays an important role in the migration of monocytes/macrophages
  • LRFN4, LRFN5 possess synaptogenic activity, inducing presynaptic differentiation in contacting axons
  • uniquely increases the number of primary processes extending from the cell body
  • functioned in migration and morphological change (i.e. cell elongation) of monocytic cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • homomeric or heteromeric complexes in brain and heterologous cells
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PSD95 binding
  • complexed with SFN and NCK1 to mediate elongation in monocytic cells via RAC-1-mediated actin cytoskeleton reorganization
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS