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FLASH GENE
Symbol LRFN2 contributors: mct - updated : 28-02-2014
HGNC name leucine rich repeat and fibronectin type III domain containing 2
HGNC id 21226
Location 6p21.2      Physical location : 40.359.372 - 40.555.126
Synonym name
  • neurogenic extracellular SLIT2 protein homolog
  • fibronectin type III, immunoglobulin and leucine rich repeat domains 2
  • synaptic adhesion-like molecules 1
  • Synonym symbol(s) SALM1, KIAA1246, RP11-535K9, FIGLER2
    DNA
    TYPE functioning gene
    STRUCTURE 195.75 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 3144 - 789 - 2006 16828986
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   specific Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain moderately
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six extracellular leucine-rich repeats domain (LRR)
  • a fibronectin type III domain (Fn)
  • an Immunoglobulin-like domain (Ig-like) C2 type domain
  • a single transmembrane (TM) domain
  • a putative dileucine ER retention motif, which is not present in the other SALMs
  • C-terminal PDZ-binding domain (PDZ-BD), which associates with the PSD-95 family of protein, may influence cellular trafficking of SALMs to specific neuronal locations and mediating LRFN2 surface expression
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus Lrfn2 (95,68 pc)
    homolog to murine Lrfn2 (95,30 pc)
    intraspecies homolog to neurogenic extracellular SLIT2 protein
    Homologene
    FAMILY
  • Synaptic adhesion-like molecules (SALMs) family
  • superfamily of leucine-rich repeat (LRR)-containing adhesion molecules
  • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
    text in synaptic membrane and postsynaptic density fractions but also distributed in axons and dendrites
    basic FUNCTION
  • neuronal component with a role in the developing or mature vertebrate nervous system
  • transmembrane adhesion-type molecule, able to subvert hematopoietic differentiation to increase erythropoiesis
  • play critical roles in the formation and maintenance of the central nervous system
  • LRFN2 functions in neurite outgrowth while LRFN1 is involved in synapse formation
  • implicated in the regulation of neurite outgrowth and branching, and synapse formation and maturation
  • having a unique mechanism of trafficking through the ER
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component homomeric or heteromeric complexes in brain and heterologous cells
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PSD95 binding
  • interacts with synapse-associated protein 102 (SAP102), and SAP97
  • also interacts with the NMDA receptor NR1 subunit through its extracellular or TM1 domains
  • directly interacts with NMDA receptors but not with AMPA receptors
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS