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FLASH GENE
Symbol LRCH4 contributors: mlc - updated : 08-12-2007
HGNC name leucine-rich repeats and calponin homology (CH) domain containing 4
HGNC id 6691
Location 7q22      Physical location : 100.171.635 - 100.183.776
Synonym name
  • leucine rich repeat neuronal 4
  • sin3-associated polypeptide, 25kDa
  • Synonym symbol(s) LRN, LRRN1, LRRN4, SAP25, PP14183, FLJ40101, FLJ46315
    DNA
    TYPE functioning gene
    STRUCTURE 12.00 kb     18 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 3201 - 683 - Olsen (2006)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
     thymus   highly
    Digestivesalivary gland   highly
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemtestis  highly
    Respiratorylung    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • nine leucine-rich repeat at the N-terminus
  • calponin homology domain
  • HOMOLOGY
    interspecies homolog to murine Lrch4
    Homologene
    FAMILY
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text membrane anchor by the C terminus
    basic FUNCTION
  • nucleocytoplasmic shuttling protein, actively exported from the nucleus by a CRM1-dependent mechanism
  • involved in ligand binding
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text neurogenesis
    PATHWAY
    metabolism
    signaling
    a component core component of the SIN3A corepressor complex whose subcellular location is regulated by PML (promyelocytic leukemia protein)
    INTERACTION
    DNA
    RNA
    small molecule
    protein binds to the PAH1 domain of SIN3A, and associates with the SIN3A-HDAC complex
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS