Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol LPXN contributors: mct - updated : 14-01-2011
HGNC name leupaxin
HGNC id 14061
Location 11q12.1      Physical location : 58.294.345 - 58.345.639
Synonym symbol(s) LDPL, LDLP
DNA
TYPE functioning gene
STRUCTURE 51.30 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1926 43.3 386 - 2007 17640867
9 - 1892 - 391 - -
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   highly Homo sapiens
Lymphoid/Immunespleen   highly
 thymus   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly Homo sapiens
Muscularsmoothvessel   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte Homo sapiens
Blood/Hematopoieticmonocyte
Skeletonosteoclast
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four leucine-rich sequences termed LD motifs, and LD3 motif, which is critical for stable association with FAK, was dispensable for leupaxin suppressive ability
  • several protein-binding domains that have been implicated in targeting proteins such as focal adhesion kinase (pp125FAK) to focal adhesions
  • HOMOLOGY
    Homologene
    FAMILY
  • paxillin (PXN) family
  • CATEGORY adhesion , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    text
  • functional nuclear export signals in its LD3 and LD4 motifs, thus shuttling between the cytoplasm and the nucleus
  • basic FUNCTION
  • playing an inhibitory role in B cell antigen receptor (BCR) signaling and B cell function
  • enriched in smooth muscle and functions as an serum response factor cofactor to induce smooth muscle cell gene transcription
  • might participating in the regulation of the signaling cascade through the binding to PEST domain tyrosine phosphatase PEP in lymphocytes
  • can undergo cytoplasmic/nuclear shuttling and functions as an serum response factor cofactor in the nucleus
  • LIM domain-containing adapter protein that has been previously reported to be preferentially expressed in hematopoietic cells
  • may be a critical nucleating component of the osteoclast podosomal signaling complex
  • may be playing an important role in carcinogenesis (Dai 2009)
  • potently represses the tyrosine phosphorylation of paxillin
  • functions as a paxillin counterpart that potently suppresses the tyrosine phosphorylation of paxillin during integrin signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of a signaling complex with PTK2B, CSK, and PTPN12 to regulate migration of prostate cancer cells
  • component of the sealing zone in osteoclasts
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the androgen receptor in a ligand-dependent manner and serves as a transcriptional activator of this hormone receptor in prostate cancer cells
  • association with SRC adds further complexity to the organization of the podosomal signaling complex in osteoclasts
  • associate with several podosomal proteins, such as the protein tyrosine kinase PYK2, PTPN12, actin-binding proteins, and regulators of actin cytoskeletal reorganization
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with RUNX1 in an acute myeloid leukemia (AML) patient with t(11;21)(q12;q22)
    tumoral     --over  
    in prostate cancer (PCa) as compared with normal prostate tissue
    constitutional     --low  
    resulted in reduced osteoclast-mediated resorption
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • could function as a putative target for therapeutic interventions of a subset of advanced prostate cancer
  • ANIMAL & CELL MODELS