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FLASH GENE
Symbol LPXN contributors: mct - updated : 14-01-2011
HGNC name leupaxin
HGNC id 14061
Location 11q12.1      Physical location : 58.294.345 - 58.345.639
Synonym symbol(s) LDPL, LDLP
DNA
TYPE functioning gene
STRUCTURE 51.30 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC390184 11 similar to seven transmembrane helix receptor LOC283193 11q12.1 similar to seven transmembrane helix receptor HCP26 11q12.1 cytochrome c, somatic pseudogene LOC219952 11q12.1 similar to Olfactory receptor 6Q1 LOC387771 11 LOC387771 LOC219953 11q12.1 similar to seven transmembrane helix receptor LOC219954 11q12.1 similar to Olfactory receptor 9I1 OR9I2P 11q13.1 olfactory receptor, family 9, subfamily I, member 2 pseudogene LOC219956 11q12.1 similar to Olfactory receptor 9Q1 LOC219957 11q12.1 similar to seven transmembrane helix receptor LOC219958 11q12.1 similar to Olfactory receptor 1S2 LOC219959 11q12.1 similar to Olfactory receptor 1S1 LOC219960 11q12.1 similar to Olfactory receptor 10Q1 LOC387772 11 similar to seven transmembrane helix receptor LOC219964 11q12.1 similar to Olfactory receptor 10Q1 LOC390185 11 similar to Olfactory receptor 5B13 LOC390186 11 similar to Olfactory receptor 5B2 (OST073) LOC219965 11q12.1 similar to Olfactory receptor 5B17 LOC390187 11 similar to Olfactory receptor 5B13 LOC390188 11 similar to Olfactory receptor 5B17 LOC390189 11 similar to Olfactory receptor 5B13 LOC390190 11 similar to Olfactory receptor 5B2 (OST073) LOC390191 11 similar to Olfactory receptor 5B16 LOC219968 11q12.1 similar to olfactory receptor MOR202-4 LPXN 11cen-q12.3 leupaxin ZFP91-CNTF 11q12.2 zinc finger protein 91 homolog (mouse), ciliary neurotrophic factor transcription unit ZFP91 11q12 zinc finger protein 91 homolog (mouse) CNTF 11q12.2 ciliary neurotrophic factor GLYAT 11q12.3 glycine-N-acyltransferase BXMAS2-10 11q12.2 BXMAS2-10 MGC15937 11q12.2 similar to RIKEN cDNA 0610008P16 gene LOC387773 11 similar to MGC15937 protein
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1926 43.3 386 - 2007 17640867
9 - 1892 - 391 - -
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   highly Homo sapiens
Lymphoid/Immunespleen   highly
 thymus   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly Homo sapiens
Muscularsmoothvessel   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte Homo sapiens
Blood/Hematopoieticmonocyte
Skeletonosteoclast
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four leucine-rich sequences termed LD motifs, and LD3 motif, which is critical for stable association with FAK, was dispensable for leupaxin suppressive ability
  • several protein-binding domains that have been implicated in targeting proteins such as focal adhesion kinase (pp125FAK) to focal adhesions
  • HOMOLOGY
    Homologene
    FAMILY
  • paxillin (PXN) family
  • CATEGORY adhesion , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    text
  • functional nuclear export signals in its LD3 and LD4 motifs, thus shuttling between the cytoplasm and the nucleus
  • basic FUNCTION
  • playing an inhibitory role in B cell antigen receptor (BCR) signaling and B cell function
  • enriched in smooth muscle and functions as an serum response factor cofactor to induce smooth muscle cell gene transcription
  • might participating in the regulation of the signaling cascade through the binding to PEST domain tyrosine phosphatase PEP in lymphocytes
  • can undergo cytoplasmic/nuclear shuttling and functions as an serum response factor cofactor in the nucleus
  • LIM domain-containing adapter protein that has been previously reported to be preferentially expressed in hematopoietic cells
  • may be a critical nucleating component of the osteoclast podosomal signaling complex
  • may be playing an important role in carcinogenesis (Dai 2009)
  • potently represses the tyrosine phosphorylation of paxillin
  • functions as a paxillin counterpart that potently suppresses the tyrosine phosphorylation of paxillin during integrin signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of a signaling complex with PTK2B, CSK, and PTPN12 to regulate migration of prostate cancer cells
  • component of the sealing zone in osteoclasts
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the androgen receptor in a ligand-dependent manner and serves as a transcriptional activator of this hormone receptor in prostate cancer cells
  • association with SRC adds further complexity to the organization of the podosomal signaling complex in osteoclasts
  • associate with several podosomal proteins, such as the protein tyrosine kinase PYK2, PTPN12, actin-binding proteins, and regulators of actin cytoskeletal reorganization
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with RUNX1 in an acute myeloid leukemia (AML) patient with t(11;21)(q12;q22)
    tumoral     --over  
    in prostate cancer (PCa) as compared with normal prostate tissue
    constitutional     --low  
    resulted in reduced osteoclast-mediated resorption
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • could function as a putative target for therapeutic interventions of a subset of advanced prostate cancer
  • ANIMAL & CELL MODELS