basic FUNCTION
| playing an inhibitory role in B cell antigen receptor (BCR) signaling and B cell function |
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enriched in smooth muscle and functions as an serum response factor cofactor to induce smooth muscle cell gene transcription |
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might participating in the regulation of the signaling cascade through the binding to PEST domain tyrosine phosphatase PEP in lymphocytes |
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can undergo cytoplasmic/nuclear shuttling and functions as an serum response factor cofactor in the nucleus |
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LIM domain-containing adapter protein that has been previously reported to be preferentially expressed in hematopoietic cells |
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may be a critical nucleating component of the osteoclast podosomal signaling complex |
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may be playing an important role in carcinogenesis (Dai 2009) |
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potently represses the tyrosine phosphorylation of paxillin |
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functions as a paxillin counterpart that potently suppresses the tyrosine phosphorylation of paxillin during integrin signaling |