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FLASH GENE
Symbol LPCAT4 contributors: mct - updated : 04-09-2008
HGNC name lysophosphatidylcholine acyltransferase 4
HGNC id 30059
Location 15q14      Physical location : 34.651.089 - 34.659.395
Synonym name
  • acyltransferase like 3
  • 1-acylglycerol-3-phosphate O-acyltransferase 7 (lysophosphatidic acid acyltransferase, eta)
  • PLSC-domain containing protein
  • acyl-CoA:lysophosphatidylethanolamine acyltransferase 2
  • Synonym symbol(s) LPAAT-eta, AYTL3, AYTL3, AGPAT7, LPEAT2, FLJ10257, MBOAT2
    EC.number 2.3.1.51
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 8.31 kb     14 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 1908 57.2 524 - 2008 18458083
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     intestinelarge intestinecolon highly
    Lymphoid/Immunethymus   highly
    Nervousbrain   predominantly
     nerve   highly
    Reproductivefemale systemovary  moderately
    Respiratorylung   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Muscularstriatumskeletal  
    cell lineage
    cell lines HELA cells
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an acyltransferase domain in 123-234 aa
  • four conserved motifs (IIV), whose invariant residues appear to be important for catalysis and/or substrate recognition
  • HOMOLOGY
    interspecies homolog to murine Aytl3
    Homologene
    FAMILY
  • 1-acyl-sn-glycerol-3-phosphate acyltransferase family
  • glycerolipid acyltransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text localized to the endoplasmic reticulum in Hela cells
    basic FUNCTION
  • acting as an acyltransferase
  • converting lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone
  • important enzyme in the biosynthesis of ethanolamine-containing phospholipids, especially in brain
  • can acylate multiple, but distinct lysophospholipids, also facilitates the acylation of several other lysophospholipids
  • possible role in modulating brain phospholipid composition
  • may play an important role in phospholipid remodeling and phosphatidylethanolamine enrichment in the brain
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate , lipid/lipoprotein
    signaling
  • synthesis of glycerolipids
  • triacylglylcerol biosynthesis
  • a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS