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FLASH GENE
Symbol LPCAT2 contributors: mct - updated : 09-03-2017
HGNC name lysophosphatidylcholine acyltransferase 2
HGNC id 26032
Location 16q12.2      Physical location : 55.542.912 - 55.620.581
Synonym name
  • hypothetical protein AYTL1
  • acyltransferase like 1
  • lyso-platelet-activating factor (PAF) acetyltransferase
  • 1-acylglycerol-3-phosphate-O-acyltransferases
  • Synonym symbol(s) FLJ20481, DKFZp686H22112, AYTL1, LysoPAFAT, AGPAT11,
    EC.number 2.3.1.23/ 2.3.1.51
    DNA
    TYPE functioning gene
    STRUCTURE 77.67 kb     14 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 5395 60 544 - 2011 21498505
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • phospholipid/glycerol acyltransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text
  • LPCAT1 and LPCAT2 can localize to the lipid droplets (LDs)surface
  • basic FUNCTION
  • acyltransferase activity
  • LPCAT1 and LPCAT2 have, in addition to their known function in specialized cells, a ubiquitous role in lipid droplets (LDs)-associated lipid metabolism
  • under inflammatory conditions, LPCAT2, but not LPCAT1, is activated and upregulated to produce platelet-activating factor (PAF)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • platelet-activating factor (PAF), a potent proinflammatory lipid mediator, is synthesized rapidly in response to extracellular stimuli by the activation LPCAT2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast, cervical, and colorectal cancer tissues, indicating its adjuvant role in the progression of these cancers
    constitutional     --over  
    in the ipsilateral spinal cord after injury
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS