Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol LPAR3 contributors: mct/npt - updated : 23-04-2008
HGNC name lysophosphatidic acid receptor 3
HGNC id 14298
Location 1p22.3-p31.1      Physical location : 85.279.085 - 85.358.896
Synonym name
  • endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 7
  • calcium-mobilizing lysophosphatidic acid receptor LP-A3
  • LPA receptor EDG7
  • Synonym symbol(s) GPCR, LP-A3, HOFNH30, RP4-678I3, EDG7, LPA-3 , FLJ98231
    DNA
    TYPE functioning gene
    STRUCTURE 52.00 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 4300 40.1 353 prostate highly Bandoh
    - splicing 1100 40.3 354 placenta Fitzgerald
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemovary  lowly
     male systemtestis   
     male systemprostate   
    Respiratoryrespiratory tractlarynx   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumenthair follicle cell
    cell lineage
    cell lines some cancer cell lines lowly
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane domains (7TM)
  • HOMOLOGY
    interspecies homolog to murine Edg7
    homolog to C.elegans C40C9.5
    homolog to Drosophila CG1062
    Homologene
    FAMILY
  • G-protein-coupled receptor family
  • EDG family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • mediating lysophosphatidic acid-evoked calcium mobilization
  • activating adenylyl-cyclase
  • functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling neurotransmission
    synaptic transmission (neuronal transmission)
    a component
  • coupled predominantly to G(9/11) alpha protein
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other lipid
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS