Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol LPAR1 contributors: mct - updated : 20-10-2012
HGNC name lysophosphatidic acid receptor
HGNC id 3166
Location 9q31.3      Physical location : 113.636.055 - 113.800.365
Synonym name
  • ventricular zone gene 1, murine homolog
  • endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2
  • Synonym symbol(s) LPA2, VZG1, GPCR26, MREC1.3, REC1.3, EDG2
    DNA
    TYPE functioning gene
    STRUCTURE 164.31 kb     5 Exon(s)
    MAPPING cloned Y linked   status tentative : very preliminary evidence
    RNA
    TRANSCRIPTS type messenger
    text alternate translation start : isoforms differing in the N terminal extracellular tail, an alternate polyadenylation site
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 splicing 3104 41.1 364 - 2000 10922489
    encoding the same protein than variant 2
    5 splicing 3182 41.1 364 - 2000 10922489
    encoding the same protein than variant 1
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Nervousbrain   predominantly
     spinal cord   highly Mus musculus
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousastrocyte Homo sapiens
    Nervousependymal cell Mus musculus
    not specificsynoviocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    seven transmembrane domains (7TM)
    conjugated GlycoP , LipoP , PhosphoP
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Gpcr26/Edg2
    ortholog to Drosophila mbf1
    ortholog to C.elegans H21P03.1
    Homologene
    FAMILY G protein coupled receptor superfamily
    CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I membrane protein
    basic FUNCTION
  • involved in the control of myelination
  • activating phospholipase C
  • LPA1/LPAR1 is involved in the regulation of bone cell activity
  • LPAR1 and ITGA4 regulate peripheral blood monocyte counts
  • promotes epithelial cell apoptosis induced by bleomycin injury
  • promotes epithelial cell apoptosis after lung injury
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • CD97 heterodimerized and functionally synergized with LPAR1, a GPCR implicated in cancer progression
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • lysophosphatidic acid (ligand of EDG2)
  • RALA and ADRBK1 are key regulators of LPAR1 signalling (LPAR1 activity therefore facilitates the formation of a novel protein complex between these two proteins)
  • CD97 functioned to mediate invasion in prostate cancer cells, at least in part, by associating with lysophosphatidic acid receptor 1 (LPAR1)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       gain of function
    in response to brain injury
    Susceptibility to knee osteoarthritis
    Variant & Polymorphism SNP increasing the risk of knee osteoarthritis
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice lacking the Lpar1 exhibit motor, emotional and cognitive alterations