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FLASH GENE
Symbol LPA contributors: mct - updated : 23-04-2008
HGNC name lipoprotein, Lp(a)
HGNC id 6667
Corresponding disease
LPA lipoprotein A congenital deficiency
Location 6q26-q27      Physical location : 160.952.515 - 161.087.407
Synonym name
  • antiangiogenic AK38 protein
    • Synonym symbol(s) LP, AK38, APOA
    EC.number 3.4.21.-
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text part of the cluster SLC22A3-LPAL2-LPA
    STRUCTURE 134.00 kb     40 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Map cen - LPAL1 - PLG PLG - LPA LPA - LPAL2 - qter
    Authors Magnaghi (94)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    40 - 6489 - 2040 - Shen (2008)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumenthair follicle cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • ten types of cysteine-rich, kringle KIV modules, one of which KIV-2 occuring in variable number, from 2 to >40
  • a protease domain (peptidase S1 domain)
    • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to PLG
    Homologene
    FAMILY peptidase S1 family, plasminogen subfamily
    CATEGORY secretory
    SUBCELLULAR LOCALIZATION extracellular
    text plasma
    basic FUNCTION
  • protease, potential modulator of blood-clotting process
  • having serine proteinase activity, and being able of autoproteolysis
  • playing a crucial role in the maintenance of hair growth
  • association of CCL2 with OLR1 and LPA may play a role in modulating monocyte trafficking during atherogenesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • Lpa is a complex of apoliprotein and one glycoprotein both linked by a single disulfide
    • INTERACTION
    DNA
    RNA
    small molecule
    protein receptor P2RY5
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LPA
    Susceptibility
  • to IDDM (IDDM8)
  • to severe coronary artery disease (CAD)
    • Variant & Polymorphism SNP , other
  • affecting plasma concentration of LPA
  • I4399M SNP is associated with severe CAD and plasma lipoprotein(a) levels
  • four SNPs overlapping the SLC22A3-LPAL2-LPA gene cluster associated to risk of coronary artery disease (Tregouet 2009)
    • Candidate gene
    Marker
    Therapy target therapeutic approaches in the treatment of hair loss
    ANIMAL & CELL MODELS