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FLASH GENE
Symbol LOXL3 contributors: npt/ - updated : 28-08-2003
HGNC name lysyl oxidase-like 3
HGNC id 13869
Location 2p13.1      Physical location : 74.759.945 - 74.781.062
Synonym name lysyl oxidase homolog 3
Synonym symbol(s) LOXL
EC.number 1.4.3.13
DNA
TYPE functioning gene
SPECIAL FEATURE
text PRSS25
STRUCTURE 21.12 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
MTHFD2 2p12 methylene tetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase SLC4A5 2p13 solute carrier family 4, sodium bicarbonate cotransporter, member 5 DCTN1 2p13 dynactin 1 (p150, glued homolog, Drosophila) LOC388963 2 similar to Retinol dehydrogenase 12 LOC257200 2p13.1 similar to high mobility group AT-hook 1 FLJ12953 2p13.1 hypothetical protein FLJ12953 similar to Mus musculus D3Mm3e RTKN 2p13 rhotekin HMGA1L4 2p13.1 high mobility group AT-hook 1-like 4 WBP1 2p12 WW domain binding protein 1 GCS1 2p13 WW domain binding protein 1 MRPL53 2p13.1 mitochondrial ribosomal protein L53 LOC151534 2p13.1 hypothetical protein BC009264 FLJ14397 2p13.1 hypothetical protein FLJ14397 FLJ12788 2p13.1 hypothetical protein FLJ12788 NSPC1 2p13.1 likely ortholog of mouse nervous system polycomb 1 TLX2 2p13.1-p12 T-cell leukemia, homeobox 2 DQX1 2p12 T-cell leukemia, homeobox 2 AUP1 2p13 ancient ubiquitous protein 1 PRSS25 2p13.3 protease, serine, 25 LOXL3 2p13.3 lysyl oxidase-like 3 DOK1 2p13 docking protein 1, 62kDa (downstream of tyrosine kinase 1) LOC130951 2p13.1 hypothetical protein BC014602 SEMA4F 2p13 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 3121 - 753 - Akagawa (2007)
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
Cardiovascularheart   highly
Digestiveintestinesmall intestine  highly
Nervousbrainhindbrainmedulla oblongata highly
 spinal cord   highly
Reproductivefemale systemovary  highly
 male systemtestis  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Connective    
Lymphoid    
Nervouscentral   
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text highly in placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal
  • four scavenger receptor cysteine-rich domains
  • one copper binding site
  • four histidyl residues
  • five N glycosylation sites
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • lysyl oxidase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    text extracellular matrix
    basic FUNCTION
  • modulating the formation of a collagenous extracellular matrix
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • copper Cu2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS