basic FUNCTION
| extracellular, copper-dependent enzyme that initiates the cross-linking of collagens and elastin by catalyzing the oxidative deamination of peptidyl lysine to alpha-aminoadipic-delta-semialdehyde |
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plays an essential role in the formation of extracellular matrix and connective tissue |
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plays a part in epithelial-mesenchymal transition (EMT) by stabilizing the transcription factor SNAI1 |
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functions as an amine oxidase for formation of lysine-derived cross-links found in collagen and elastin |
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promotes invasion in breast cancer by regulating the expression and activity of the extracellular proteins tissue inhibitor of metalloproteinase-1 (TIMP1) and matrix metalloproteinase-9 (MMP9) |
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induces epithelial to mesenchymal transition and promotes invasiveness |
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its expression is required for ATDC5 chondrocyte cell line differentiation through regulation of SNAIL and SOX9, important transcription factors that control chondrocyte differentiation |
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promotes chondrocyte differentiation by mechanisms that are likely to include roles as both a regulator and an effector of chondrocyte differentiation |
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likely playing a vital role in chondrogenesis |
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inhibits the differentiation of keratinocytes promoting development of squamous cell carcinomas, but its enzymatic activity is not required for LOXL2-induced inhibition of keratinocyte differentiation |
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LOXL2, and LOXL4, promote invasion and metastatic niche formation |
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having intracellular functions, such as its involvement in the regulation of the epithelial-to-mesenchymal transition, epithelial cell polarity and differentiation mediated by transcriptional repression mechanisms |
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matrix-remodeling enzyme shown to play a key role in invasion and metastasis of breast carcinoma cells |
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tumor- secreted LOXL2 activated fibroblasts through integrin-mediated focal adhesion kinase activation |
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controls tumor-associated cell proliferation through the interaction with MARCKSL1 |
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critical intracellular role for LOX and LOXL2 in transcriptional regulation |
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likely regulating extracellular and intracellular cell signaling pathways |
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involved in a wide range of physiological and pathological processes, including fibrosis and tumor progression, implicating intracellular and extracellular functions |