basic FUNCTION
| lysyl oxidase, copper dependent, processed by BMP1 to the mature enzyme necessary for the formation of covalent cross-links in collagen and elastic fibers |
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playing a potential tumor suppressor role but also involved in tumor progression |
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essential for hypoxia-induced metastasis and is a good therapeutic target for preventing and treating metastases |
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key enzyme in extracellular matrix maturation |
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seems to be involved in the impairment of endothelial function triggered by different pathological conditions |
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essential for hypoxia-induced metastasis |
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its enzyme activity is critical for the biosynthesis of mature and functional collagens and elastin |
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can associate with extracellular and intracellular binding partners to affect its known biological activities as a tumor suppressor and inhibitor of cell proliferation |
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implicated in chromatin decondensation, decondensation suggested to be promoted by LOX actions on histone H1 |
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essential mediator of STK11-deficiency-elicited lung cancer progression through ECM alteration, especially collagen matrix remodeling |
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may alter cancer cell growth potential via ECM remodeling |
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lysosome may regulate the dendrite development of Purkinje cells though degradation of LOX |
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multifunctional enzyme required for collagen biosynthesis |
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plays a critical role in vascular remodelling |
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critical intracellular role for LOX and LOXL2 in transcriptional regulation |
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enzyme responsible for the formation of collagen cross-links |
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PLOD1 and lysyl oxidase (LOX), contribute to ECM maturation and stabilization |
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LOX and PLOD1 are critical players in vascular calcification, and important role of ECM remodeling in this process |