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FLASH GENE
Symbol LOR contributors: mct - updated : 25-05-2011
HGNC name loricrin
HGNC id 6663
Corresponding disease
KHM1 keratoderma (hyperkeratosis), palmoplantar, mutilans,1
PSEK1 progressive symetric erythrokeratoderma 1
Location 1q21.3      Physical location : 153.232.178 - 153.234.598
Synonym symbol(s) CEP, LRC, LRN, MGC111513
DNA
TYPE functioning gene
STRUCTURE 2.42 kb     2 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site   transcription factor
text structure
  • open reading frame in a single exon
  • AP1 site located in the proximal promoter region (position -55) essential for promoter activity
  • MAPPING cloned Y linked Y status confirmed
    Physical map
    SPRL2A 1q21.3 small proline rich-like (epidermal differentiation complex) 2A LEP1 1q21.3 late envelope protein 1 MCSP 1q21 mitochondrial capsule selenoprotein IVL 1q21 involucrin SPRR4 1q21.3 small proline rich protein 4 SPRR1A 1q21 small proline-rich protein 1A SPRR3 1q21 small proline-rich protein 3 SPRR1B 1q21 small proline-rich protein 1B (cornifin) SPRR2A 1q21 small proline-rich protein 2A SPRR2B 1q21 small proline-rich protein 2B SPRR2C 1q21 small proline-rich protein 2C LOC149018 1q22 hypothetical LOC149018 LOC391102 1 similar to 60S acidic ribosomal protein P0 (L10E) LOR 1q21 loricrin PGLYRPIalpha 1q21 peptidoglycan recognition protein-I-alpha precursor PGLYRPIbeta 1q21 peptidoglycan recognition protein-I-beta precursor S100A9 1q21 S100 calcium binding protein A9 (calgranulin B) S100A12 1q21 S100 calcium binding protein A12 (calgranulin C) LOC391103 1 similar to lysosomal-associated transmembrane protein 4 beta; putative integral membrane transporter S100A8 1q21 S100 calcium binding protein A8 (calgranulin A) S100A15 1q22 S100 calcium binding protein A15 S100A7L2 1q22 S100 calcium binding protein A7-like 2 S100A7 1q21 S100 calcium binding protein A7 (psoriasin 1) S100A6 1q21 S100 calcium binding protein A6 (calcyclin) S100A5 1q21 S100 calcium binding protein A5 S100A4 1q21 S100 calcium binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog) LOC388700 1 hypothetical gene supported by BT006955; NM_002960
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1229 25.63 312 - 1996 8618063
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningepidermis  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentcornified cell
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three long glycine-serine-cysteine rich sequence domains, forming glycine loops
  • lysine and glutamine rich domains, involved in isodipeptide cross links
  • HOMOLOGY
    Homologene
    FAMILY
  • SPRR family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • major keratinocyte cell envelope protein
  • Loricrin (LOR) and involucrin (IVL) are proteins important for skin barrier formation and integrity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • major protein constituent of the cornified cell enveloppe in stratum corneum
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by Sp1, c-Jun, an unidentified regulator, and the co-activator p300/CREB-binding protein
    inhibited by Th2 cytokines that inhibit expression of LOR and IVL through a STAT-6 dependent mechanism
    repressed by Sp3, CREB-1/CREMalpha/ATF-1, Jun B, and an AP2-like protein (termed the keratinocyte-specific repressor-1 (KSR-1))
    ASSOCIATED DISORDERS
    corresponding disease(s) KHM1 , PSEK1
    Susceptibility
    Variant & Polymorphism
    Candidate gene for PSORS4
    Marker
    Therapy target
    ANIMAL & CELL MODELS