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FLASH GENE

Symbol

LNX2

contributors: mct - updated : 14-03-2012

HGNC name	ligand of numb-protein X 2
HGNC id	20421

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	13q12.2      Physical location : 28.120.051 - 28.194.720
Synonym name	PDZ domain containing ring finger 1
Synonym symbol(s)	MGC46315, PDZRN1

DNA

TYPE	functioning gene
STRUCTURE	74.67 kb     10 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_153371 10 - 4804 NP_699202 - 690 - 2010 19701800

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine         stomach         Urinary bladder

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one RING-type zinc finger
	four PDZ domains which are proved to play a central role in organizing diverse cell signaling assemblies

HOMOLOGY

interspecies

homolog to murine Lnx2

Homologene

FAMILY

RING finger-type E3 ubiquitin ligase family

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION

basic FUNCTION	could participate in signal transduction, such as Notch pathway, and play an important role in tumorigenesis
	LNX1 or LNX2 promoted CD8A ubiquitylation, downregulation from the plasma membrane, transport to the lysosomes, and degradation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+

protein	interacting with the phosphotyrosine interaction domain of numb
	CXADR is a partner in a protein complex organized at specific subcellular sites by LNX2
	potential binding partner for RHOC (LNX1, LNX2 and RHOC might be part of a larger protein complex that would have important functions in signaling transduction about regulating the transcriptional activities of AP-1)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   could result in cell cycle arrest in G0/G1 phase through inhibition of CTNNB, MAPK, NFKB, MYC-dependent pathway and activation of TP53, TGFB-dependent pathway

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS