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FLASH GENE
Symbol LNX2 contributors: mct - updated : 14-03-2012
HGNC name ligand of numb-protein X 2
HGNC id 20421
Location 13q12.2      Physical location : 28.120.051 - 28.194.720
Synonym name PDZ domain containing ring finger 1
Synonym symbol(s) MGC46315, PDZRN1
DNA
TYPE functioning gene
STRUCTURE 74.67 kb     10 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 4804 - 690 - 2010 19701800
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
 stomach    
Urinarybladder    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one RING-type zinc finger
  • four PDZ domains which are proved to play a central role in organizing diverse cell signaling assemblies
  • HOMOLOGY
    interspecies homolog to murine Lnx2
    Homologene
    FAMILY RING finger-type E3 ubiquitin ligase family
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • could participate in signal transduction, such as Notch pathway, and play an important role in tumorigenesis
  • LNX1 or LNX2 promoted CD8A ubiquitylation, downregulation from the plasma membrane, transport to the lysosomes, and degradation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Zn2+
    protein
  • interacting with the phosphotyrosine interaction domain of numb
  • CXADR is a partner in a protein complex organized at specific subcellular sites by LNX2
  • potential binding partner for RHOC (LNX1, LNX2 and RHOC might be part of a larger protein complex that would have important functions in signaling transduction about regulating the transcriptional activities of AP-1)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    could result in cell cycle arrest in G0/G1 phase through inhibition of CTNNB, MAPK, NFKB, MYC-dependent pathway and activation of TP53, TGFB-dependent pathway
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS