Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

LNPEP

contributors: mct - updated : 16-04-2014

HGNC name	leucyl/cystinyl aminopeptidase
HGNC id	6656

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	5q15      Physical location : 96.271.345 - 96.365.115
Synonym name	insulin regulated aminopeptidase
	placenta leucine aminopeptidase/oxytocinase
	angiotensin IV receptor
	oxytocinase
	vasopressinase
	placental leucine aminopeptidase
	AT (4) receptor
Synonym symbol(s)	CAP, PLAP, IRAP, OTASE, P-LAP
EC.number	3.4.11.3

DNA

TYPE	functioning gene
SPECIAL FEATURE	gene in gene
STRUCTURE	93.77 kb     18 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

text	two iniation sites (Ramussen)

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005575 18 - 4470 NP_005566 - 1025 - Loustsen, Yeh mature mRNA NM_175920 18 initiation site 4262 NP_787116 - 1011 - Loustsen, Yeh

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node       highly Nervous brain hindbrain cerebellum     Homo sapiens   brain limbic system hippocampus     Homo sapiens Reproductive female system placenta     highly Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose       Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Nervous pyramidal cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text	placenta, predominantly expressed in differentiated trophoblasts, syncytiotrophoblasts

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an acidic intracellular region followed by a hydrophobic transmembrane segment
	a large extracellular domain containing the characteristic Zn2+ coordination motif
	a second Zn(2+) binding site, not associated with the catalytic region
	the gluzincin aminopeptidase motif GAMEN-(31 amino acids)-HELAH-(18 amino acids)-E associated with Zn2+-binding and substrate binding
	a novel RXXPDG motif mediating the binding to tankyrases

conjugated

MetalloP

HOMOLOGY

Homologene

FAMILY

peptidase M1 family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endosome
	intracellular,cytoplasm,organelle,lysosome
	intracellular,cytoplasm,cytosolic
text	type II integral membrane protein
	in dendritic cells, localized to Rab14+ endosomal storage compartment required for MHC class I cross presentation (Saveanu 2009)
	localized in a regulated endosomal storage compartment

basic FUNCTION	control of onset of labour
	potential regulator of glucose transporter isoform 4 vesicle trafficking in adipocytes
	recycling of LNPEP from the plasma membrane back to the insulin-responsive compartment requires the Q-SNARE STX6 but not the GGA clathrin adaptors
	codistributes with the insulin-responsive glucose transporter SLC2A4 in specialised vesicles, where it plays a role in the tethering and/or trafficking of these vesicles
	role for LNPEP and SLC2A4 in activity-dependent glucose uptake in hippocampal neurones
	may be involved in maintaining pregnancy homeostasis via metabolizing peptides such as oxytocin and vasopressin
	ERAP1, ERAP2, LNPEP play critical roles in the generation of antigenic peptides
	membrane-bound zinc metallopeptidase
	involved in the renin-angiotensin system, which also has a key role in cardiovascular disease and diabetes

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	? homeostasis during pregnancy

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	LNPEP binding protein, vimentin, plays an important role in retention of SLC2A4 storage vesicles (GSVs)
	largely combines the S1 specificity of ERAP1 and ERAP2, consistent with its proposed biological function
	colocalized with the endosomal markers RAB14 and syntaxin 6, both known to be associated with regulated endosomal storage compartments

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in normal gestation constitutional     --low   in the patients with preterm delivery and severe preeclampsia constitutional     --low   significantly downregulated in psoriatic lesions compared with the control skin

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS