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FLASH GENE
Symbol LNPEP contributors: mct - updated : 16-04-2014
HGNC name leucyl/cystinyl aminopeptidase
HGNC id 6656
Location 5q15      Physical location : 96.271.345 - 96.365.115
Synonym name
  • insulin regulated aminopeptidase
  • placenta leucine aminopeptidase/oxytocinase
  • angiotensin IV receptor
  • oxytocinase
  • vasopressinase
  • placental leucine aminopeptidase
  • AT (4) receptor
  • Synonym symbol(s) CAP, PLAP, IRAP, OTASE, P-LAP
    EC.number 3.4.11.3
    DNA
    TYPE functioning gene
    SPECIAL FEATURE gene in gene
    STRUCTURE 93.77 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text two iniation sites (Ramussen)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 4470 - 1025 - Loustsen, Yeh
    mature mRNA
    18 initiation site 4262 - 1011 - Loustsen, Yeh
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
    Nervousbrainhindbraincerebellum   Homo sapiens
     brainlimbic systemhippocampus   Homo sapiens
    Reproductivefemale systemplacenta  highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose   
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervouspyramidal cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta, predominantly expressed in differentiated trophoblasts, syncytiotrophoblasts
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an acidic intracellular region followed by a hydrophobic transmembrane segment
  • a large extracellular domain containing the characteristic Zn2+ coordination motif
  • a second Zn(2+) binding site, not associated with the catalytic region
  • the gluzincin aminopeptidase motif GAMEN-(31 amino acids)-HELAH-(18 amino acids)-E associated with Zn2+-binding and substrate binding
  • a novel RXXPDG motif mediating the binding to tankyrases
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • peptidase M1 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic
    text
  • type II integral membrane protein
  • in dendritic cells, localized to Rab14+ endosomal storage compartment required for MHC class I cross presentation (Saveanu 2009)
  • localized in a regulated endosomal storage compartment
  • basic FUNCTION
  • control of onset of labour
  • potential regulator of glucose transporter isoform 4 vesicle trafficking in adipocytes
  • recycling of LNPEP from the plasma membrane back to the insulin-responsive compartment requires the Q-SNARE STX6 but not the GGA clathrin adaptors
  • codistributes with the insulin-responsive glucose transporter SLC2A4 in specialised vesicles, where it plays a role in the tethering and/or trafficking of these vesicles
  • role for LNPEP and SLC2A4 in activity-dependent glucose uptake in hippocampal neurones
  • may be involved in maintaining pregnancy homeostasis via metabolizing peptides such as oxytocin and vasopressin
  • ERAP1, ERAP2, LNPEP play critical roles in the generation of antigenic peptides
  • membrane-bound zinc metallopeptidase
  • involved in the renin-angiotensin system, which also has a key role in cardiovascular disease and diabetes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text ? homeostasis during pregnancy
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LNPEP binding protein, vimentin, plays an important role in retention of SLC2A4 storage vesicles (GSVs)
  • largely combines the S1 specificity of ERAP1 and ERAP2, consistent with its proposed biological function
  • colocalized with the endosomal markers RAB14 and syntaxin 6, both known to be associated with regulated endosomal storage compartments
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in normal gestation
    constitutional     --low  
    in the patients with preterm delivery and severe preeclampsia
    constitutional     --low  
    significantly downregulated in psoriatic lesions compared with the control skin
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS