SUBCELLULAR LOCALIZATION
| extracellular
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| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endosome
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| intracellular,cytoplasm,organelle,lysosome
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| intracellular,cytoplasm,cytosolic
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text
| type II integral membrane protein |
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in dendritic cells, localized to Rab14+ endosomal storage compartment required for MHC class I cross presentation (Saveanu 2009) |
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localized in a regulated endosomal storage compartment  |
basic FUNCTION
| control of onset of labour |
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potential regulator of glucose transporter isoform 4 vesicle trafficking in adipocytes |
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recycling of LNPEP from the plasma membrane back to the insulin-responsive compartment requires the Q-SNARE STX6 but not the GGA clathrin adaptors  |
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codistributes with the insulin-responsive glucose transporter SLC2A4 in specialised vesicles, where it plays a role in the tethering and/or trafficking of these vesicles  |
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role for LNPEP and SLC2A4 in activity-dependent glucose uptake in hippocampal neurones  |
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may be involved in maintaining pregnancy homeostasis via metabolizing peptides such as oxytocin and vasopressin |
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ERAP1, ERAP2, LNPEP play critical roles in the generation of antigenic peptides  |
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membrane-bound zinc metallopeptidase  |
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involved in the renin-angiotensin system, which also has a key role in cardiovascular disease and diabetes  |