SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
|
| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,Golgi
|
| intracellular,cytoplasm,organelle,endosome
|
| intracellular,cytoplasm,cytosolic,vesicle
|
text
| integral to membrane |
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localizes to cytoplasmic membrane vesicles and to perinuclear recycling endosomes |
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serine/threonine kinase predominantly localized to endosomal compartments |
basic FUNCTION
| apoptosis associated tyrosine kinase |
|
involved in neural development and functions during the early postnatal period |
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playing important roles in NGF-TrkA signaling |
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functioning as a myosin VI-interacting protein, involved in endosomal membrane trafficking |
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critical for the transition of endocytosed membrane vesicles from early endosomes to recycling endosomes, suggesting an involvement of myosin VI in this pathway |
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LMTK2 may regulate the activity of kinesin-1 motor function and SMAD2 signalling |
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transmembrane protein with serine and threonine but not tyrosine kinase activity |
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involved in the trafficking of the CFTR ion channel, the androgen receptor, as well as modulating neurodegeneration |