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FLASH GENE
Symbol LMTK2 contributors: mct/npt - updated : 08-09-2016
HGNC name lemur tyrosine kinase 2
HGNC id 17880
Location 7q21.3      Physical location : 97.736.196 - 97.838.942
Synonym name
  • murine apoptosis associated tyrosine kinase
  • kinase phosphatase inhibitor 2
  • neuronal kinase, cyclin-dependent kinase 5 (cdk5)/p35-regulated kinase (cprk)
  • brain-enriched kinase
  • Synonym symbol(s) KIAA1079, KPI2, LMR2, cprk, BREK, AATYK2, PPP1R100, hBREK
    EC.number 2.7.11.1
    DNA
    TYPE like-sequence
    STRUCTURE 102.77 kb     14 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 8961 165 1503 - 2008 18264097
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Lymphoid/Immunelymph node   highly
    Nervousbrain    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two N-terminal membrane-spanning domains
  • a long C terminus, which harbors a dual-specificity serine/threonine/tyrosine kinase domain, and a di-acidic ER export motif, used by LMTK2 for its efficient export from the ER
  • HOMOLOGY
    interspecies homolog to murine apoptosis associated tyrosine kinase
    Homologene
    FAMILY
  • protein serine/threonine kinases family
  • CATEGORY enzyme , regulatory , receptor membrane serine/threonine
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • integral to membrane
  • localizes to cytoplasmic membrane vesicles and to perinuclear recycling endosomes
  • serine/threonine kinase predominantly localized to endosomal compartments
  • basic FUNCTION
  • apoptosis associated tyrosine kinase
  • involved in neural development and functions during the early postnatal period
  • playing important roles in NGF-TrkA signaling
  • functioning as a myosin VI-interacting protein, involved in endosomal membrane trafficking
  • critical for the transition of endocytosed membrane vesicles from early endosomes to recycling endosomes, suggesting an involvement of myosin VI in this pathway
  • LMTK2 may regulate the activity of kinesin-1 motor function and SMAD2 signalling
  • transmembrane protein with serine and threonine but not tyrosine kinase activity
  • involved in the trafficking of the CFTR ion channel, the androgen receptor, as well as modulating neurodegeneration
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
  • ATP
  • protein
  • interaction of myosin VI with LMTK2
  • regulates a known pathway that controls phosphorylation of kinesin-1 light chain-2 (KLC2) by glycogen synthase kinase-3&
  • 946; (GSK3B)
  • CFTR is a substrate of LMTK2, and phosphorylates CFTR-Ser(737) in human airway epithelial cells
  • cell & other
    REGULATION
    Other regulated in the brain by CDK5/p35
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to prostate cancer
    Variant & Polymorphism SNP increasing the risk of prostate cancer
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    pharmacologic manipulation of LMTK2 activity will provide a novel therapeutic target for more effective treatments for patients with castrate-resistant prostate cancer
    ANIMAL & CELL MODELS