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FLASH GENE

Symbol

LMOD3

contributors: mct - updated : 15-05-2018

HGNC name	leiomodin 3 (fetal)
HGNC id	6649

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	NEM10 nemaline myopathy 10
Location	3p14.1      Physical location : 69.156.038 - 69.171.746
Synonym name	leiomodin, fetal form
Synonym symbol(s)	DKFZp313F0135, NEM10

DNA

TYPE	functioning gene
STRUCTURE	13.92 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001304418 4 - 2221 NP_001291347 64.8 560 - 2014 25250574 NM_198271 3 - 2315 NP_938012 64.8 560 - 2014 25250574

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

tropomodulin family

CATEGORY

antigen

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton

basic FUNCTION	involved in tropomyosin binding
	appropriate levels of both TMOD4 and LMOD3 are required for embryonic myofibrillogenesis and, both proteins can function redundantly during skeletal muscle thin filament assembly
	is required in the fast fibers for sarcomere integrity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

TMOD1 and TMOD4 cap thin filament pointed ends and functionally interact with the LMOD isoforms LMOD2 and LMOD3 to control myofibril organization, thin filament lengths, and actomyosin crossbridge formation in skeletal muscle fibers

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

NEM10

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Lmod3(PB/PB) mice show severe muscle weakness and postnatal growth retardation