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FLASH GENE
Symbol LMO7 contributors: mct - updated : 30-01-2012
HGNC name LIM domain only 7
HGNC id 6646
Location 13q22.2      Physical location : 76.194.569 - 76.434.004
Synonym name
  • LOMP protein
  • F-box protein Fbx20
  • F-box only protein 20
  • zinc-finger domain-containing protein
  • Synonym symbol(s) KIAA0858, LOMP, FBX20, FBXO20
    DNA
    TYPE functioning gene
    STRUCTURE 239.44 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    DACH 13q21-q22 dachshund homolog (Drosophila) FLJ22624 13q21.33 FLJ22624 protein DIS3 13q21.33 FLJ22624 protein PIBF1 13q21.33 progesterone-induced blocking factor 1 LOC338091 13q21 proteasome 26S non-ATPase subunit 10 pseudogene KLF5 13q21.33 Kruppel-like factor 5 (intestinal) LOC387934 13 similar to Fatty acid-binding protein, epidermal (E-FABP) (Psoriasis-associated fatty acid-binding protein homolog) (PA-FABP) LOC122134 13q21.33 similar to MAP/microtubule affinity-regulating kinase 3 LOC387935 13 LOC387935 KLF12 13q22 Kruppel-like factor 12 LOC122145 13q21.33 suppressor of bimD6 homolog pseudogene LOC387936 13 hypothetical gene supported by AL133018 LOC387937 13 LOC387937 TBC1D4 13q22 TBC1 domain family, member 4 AK000009  Acrg embryonic lethality (mouse) minimal region ortholog UCHL3 13q22 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) LMO7 13q22 LIM domain only 7 KCTD12 13q21 potassium channel tetramerisation domain containing 12 BTF3L1 13q22 basic transcription factor 3, like 1 LOC341720 13q22.1 similar to immune-responsive gene 1 LOC390413 13 similar to 60S ribosomal protein L7 DHX9P 13q21 DEAH (Asp-Glu-Ala-His) box polypeptide 9 pseudogene CLN5 13q22 ceroid-lipofuscinosis, neuronal 5 FBXL3A 13q22 F-box and leucine-rich repeat protein 3A PAM 5q15 peptidylglycine alpha-amidating monooxygenase SCEL 13q22 sciellin LOC390414 13 similar to chromosome 15 open reading frame 2 FLJ30046 13q22.1 hypothetical protein FLJ30046 EDNRB 13q22 endothelin receptor type B POU4F1 13q21.1-q22 POU domain, class 4, transcription factor 1 C13orf7 13q22.2 chromosome 13 open reading frame 7 LOC341732 13q22.2 similar to 60 kDa heat shock protein, mitochondrial precursor (Hsp60) (60 kDa chaperonin) (CPN60) (Heat shock protein 60) (HSP-60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) (HuCHA60) LOC390415 13 similar to T-complex protein 1, epsilon subunit (TCP-1-epsilon) (CCT-epsilon) C13orf10 13q22.1 chromosome 13 open reading frame 10 NDFIP2 13q22.1 Nedd4 family interacting protein 2 SPRY2 13q31-q32 sprouty homolog 2 (Drosophila)
    RNA
    TRANSCRIPTS type messenger
    text multiple alternative splice variants but their full length sequence have not been determined
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    30 - 7253 - 1349 - 2006 17067998
    27 - 6791 - 1385 - 2006 17067998
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus   lowly
    Cardiovascularheart   highly
    Digestiveintestinelarge intestinecolon lowly
     liver   lowly
    Endocrineadrenal gland   lowly
     pancreas    
    Nervousbrain    
     spinal cord   lowly
    Reproductivemale systemtestis  lowly
     male systemprostate  lowly
    Respiratorylung   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    Muscularstriatumskeletal  
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text lung,heart
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a calponin homology (CH) domain, a one PDZ domain, a C terminal LIM domain
  • an F-Box (FBX) domain is present in alternative splice variants
  • HOMOLOGY
    Homologene
    FAMILY LMO gene family
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • regulating emerin gene expression
  • forming a specific protein-binding interface for protein-protein interactions
  • MLLT4- and ACTN1-binding protein that connects the PVRL1-MLLT4 and E-cadherin-catenin systems through alpha-actinin
  • regulating development
  • possible essential functions for LMO7 during vertebrate heart development
  • required for proper myoblast differentiation
  • cell-specific regulator of myocardin-related transcription factors (MRTFs) and plays an important role in breast cancer cell migration
  • colocalizes with F-actin and reduces the G-actin/F-actin ratio via a Rho-independent mechanism
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
  • binding emerin protein, and EDMD-relevant genes
  • required for emerin gene transcription
  • feedback-regulated by binding to emerin
  • bound alpha-actinin, an actin filament-bundling protein, which bound to alpha-catenin
  • EMD binds to and inhibits the activity of LMO7, a transcription factor that regulates the expression of genes implicated in EMD (functional interaction between emerin and LMO7 is crucial for temporally regulating the expression of key myogenic differentiation genes)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in the stroma of invasive breast carcinoma in a manner that correlates with the increased expression of SRF target genes that regulate muscle and actin cytoskeleton functions
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    deletion of Uchl3 and Lmo7 on mouse chromosome 14 causes defects in viability, postnatal growth and degeneration of muscle and retina