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FLASH GENE
Symbol LMO4 contributors: mlct/npt - updated : 23-12-2015
HGNC name LIM domain only 4
HGNC id 6644
Location 1p22.3      Physical location : 87.794.150 - 87.814.603
Synonym name
  • LIM domain transcription factor LMO4
  • breast tumor autoantigen
    • DNA
    TYPE functioning gene
    STRUCTURE 17.00 kb     5 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence cytosine-phosphate-guanine/HTF
    MAPPING cloned Y linked N status provisional
    Map pter - D1S188 - D1S2806 - D1S192 - D1S501 - D1S411 - D1S448 - D1S219 - D1S481 - D1S2618 - D1S2876 - D1S500 - D1S2856 - D1S207 - D1S488 - D1S2774 - D1S2889 - D1S2766 - GTF2B ,LMO4 - D1S2865 - cen
    Authors Gene Map (99)
    RNA
    TRANSCRIPTS type messenger
    text two alternatively spliced 5' (non coding) exons
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 5415 18 165 - 2003 12878195
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumearinnercochlea highly
    Reproductivefemale systembreast   
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Epithelialabsorptive excretoryalveolar epithelium  
    Epithelialsecretoryglandular  
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text cranial neural crest, somites
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two N terminal cysteine-rich LIM/double zinc finger motifs (LIM domains)
    • HOMOLOGY
    interspecies homolog to murine Lmo4
    intraspecies homolog to LMO1
    Homologene
    FAMILY
  • LIM domain containing transcription factor
  • LMO subfamily
    • CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • transcriptional regulator participating to mammary gland development
  • repressor of BRCA1 in breast tissue
  • GRHL3 and LMO4 play coordinate roles in epidermal migration
  • novel cell cycle regulator with a key role in mediating ERBB2-induced proliferation, a hallmark of ERBB2-positive cancer
  • has similar cellular effects in normal mammary epithelial cells and breast cancer cells, and also provide direct evidence for the idea that normal development and carcinogenesis share conserved molecular mechanisms
  • transcription cofactor expressed during retinal development and in amacrine neurons at birth
  • essential postnatal function of LMO4 in the differentiation of BHLHB5-expressing inhibitory interneurons in the retina
  • promotes the acquisition of cortical neuronal identities by forming a complex with NEUROG2 and subsequently activating NEUROG2-dependent gene expression
    • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LDBS
  • DEAF1
  • RBBP8 and BRCA1 and inhibiting BRCA1 activity
  • interacted strongly to LDB1, which was required for the localization to the nucleus
  • LMO4 serves as a functional partner of GRHL3
  • role for transcription factor LMO4 in thymus development through genetic interaction with CITED2
  • functions as a novel co-factor of NEUROG2 in the developing cortex
  • overexpression of LMO4 may disrupt some of the normal tumour suppressor activities of RBBP8, thereby contributing to breast cancer progression
  • LDB1 in a complex with LMO4, supports mammary stem cells by directly targeting the FGFR2 promoter in basal cells to increase its expression
  • SSBP2, SSBP3 control LMO4 and LDB1 protein abundance in a cancer context
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer cell lines
    tumoral   amplification    
    in squamous cell carcinoma of the oral cavity
    tumoral     --over  
    inducing mammary hyperplasia, promotes cell invasion, and is a predictor of poor outcome in breast cancer
    tumoral     --over  
    in late stage pancreas cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS