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FLASH GENE
Symbol LMO3 contributors: mct - updated : 03-10-2018
HGNC name LIM domain only 3 (rhombotin-like 2)
HGNC id 6643
Location 12p12.3      Physical location : 16.701.306 - 16.761.024
Synonym name
  • neuronal specific transcription factor DAT1
  • rhombotin-like 2
  • rhombotin-3
  • Synonym symbol(s) LOM3, RBTNL2, DAT1, MGC26081, RBTN3, RHOM3, Rhom-3
    DNA
    TYPE functioning gene
    STRUCTURE 61.86 kb     4 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 3450 - 145 - 2017 28669928
    4 - 3727 - 145 - 2017 28669928
    5 - 3659 - 145 - 2017 28669928
    6 - 3596 - 167 - 2017 28669928
    4 - 3431 - 145 - 2017 28669928
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   predominantly
    Respiratorylung   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text in the developing CNS, primarily in diencephalic and telencephalic structures and a subset of lymphoid tissues,also found in embryonic spinal chord and fetal liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two N-terminal cysteine-rich LIM/double zinc finger motifs (LIM domains)
  • a homeobox DNA-binding domain
  • HOMOLOGY
    interspecies homolog to murine Lmo3 (100.0pc)
    Homologene
    FAMILY
    CATEGORY regulatory , transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text associated with NHLH2 in the nucleus (Aoyama 2005)
    basic FUNCTION
  • transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types
  • potential role of the CIB1/LMO3 complex is to inhibit cell proliferation
  • acting as a corepressor of TP53, suppressing its transcriptional activity without inhibition of its DNA-binding activity (Larsen 2010)
  • is a regulator of human adipogenesis and could contribute a mechanism resulting in visceral-fat accumulation in obesity due to excess glucocorticoids
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • calcium- and integrin-binding protein CIB1 is an LMO3-binding protein, which binds via the second LIM domain (LIM2) of LMO3
  • interacting with TP53, facilitating its binding to its response elements (Larsen 2010)
  • transcriptional complex of LMO3 and NHLH2 may contribute to the genesis and malignant phenotype of neuroblastoma by inhibiting HES1 which suppresses the transactivation of ASCL1
  • LMO3 is a putative direct transcriptional target of GBX2 (GBX2 regulates the LIM transcriptional codes comprising LHX2, LHX9 and LMO3, which subsequently control the differential expression of ROBO1 and ROBO2 in the thalamus
  • LMO3 is a Ssubstantia nigra -specific co-regulator of PITX3-dependent transcription
  • GATA4 and LMO3 balance angiocrine signaling and autocrine inflammatory activation by BMP2 in liver sinusoidal endothelial cells
  • promotes hepatocellular carcinoma invasion, metastasis and anoikis inhibition by directly interacting with LATS1 and suppressing Hippo signaling
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    higher expression in unfavorable neuroblastomas compared with those of favorable tumors (Aoyama 2005)
    tumoral     --other  
    SH3BP5, LMO3, and SNAP25, were detected in diffuse large B-cell lymphoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • acting as an oncogene in neuroblastoma (Aoyama 2005)
  • Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    may serve as a potential therapeutic target for HCC in future
    ANIMAL & CELL MODELS
  • heterozygous Lmo3 and Hen2 transgenic mice (Tg (Lmo3) and Tg (Hen2)) developed hydrocephalus at higher frequency than for the wild type mice, and all heterozygous double-transgenic mice (Tg (Lmo3; Hen2)) developed hydrocephalus