protein
| calcium- and integrin-binding protein CIB1 is an LMO3-binding protein, which binds via the second LIM domain (LIM2) of LMO3 |
|
interacting with TP53, facilitating its binding to its response elements (Larsen 2010) |
|
transcriptional complex of LMO3 and NHLH2 may contribute to the genesis and malignant phenotype of neuroblastoma by inhibiting HES1 which suppresses the transactivation of ASCL1 |
|
LMO3 is a putative direct transcriptional target of GBX2 (GBX2 regulates the LIM transcriptional codes comprising LHX2, LHX9 and LMO3, which subsequently control the differential expression of ROBO1 and ROBO2 in the thalamus |
|
LMO3 is a Ssubstantia nigra -specific co-regulator of PITX3-dependent transcription |
|
GATA4 and LMO3 balance angiocrine signaling and autocrine inflammatory activation by BMP2 in liver sinusoidal endothelial cells |
|
promotes hepatocellular carcinoma invasion, metastasis and anoikis inhibition by directly interacting with LATS1 and suppressing Hippo signaling |
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
| --over
|  
|
higher expression in unfavorable neuroblastomas compared with those of favorable tumors (Aoyama 2005) | tumoral
|  
|  
| --other
|  
|
SH3BP5, LMO3, and SNAP25, were detected in diffuse large B-cell lymphoma | |