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FLASH GENE
Symbol LMO1 contributors: shn - updated : 01-06-2011
HGNC name LIM domain only 1 (rhombotin 1)
HGNC id 6641
Location 11p15.4      Physical location : 8.245.856 - 8.285.406
Synonym name
  • LIM domain only protein 1
  • LMO-1
  • T-cell translocation protein 1
  • cysteine-rich protein TTG-1
  • rhombotin-1
  • Synonym symbol(s) RBTN1, TTG1, RHM1, RHOM1, MGC116692
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 39.55 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map pter -D11S1331 - D11S1996 - LMO1 - D11S932 - D11S909 - cen
    Physical map
    OR10A4P 11 olfactory receptor, family 10, subfamily A, member 4 pseudogene LOC120775 11p15.4 similar to Olfactory receptor 2D3 ZNF215 11p15.4 zinc finger protein 215 ZNF214 11p15.4 zinc finger protein 214 NALP14 11p15.4 NACHT, leucine rich repeat and PYD containing 14 HNRNPG-T 11p15 testes-specific heterogenous nuclear ribonucleoprotein G-T LOC143425 11p15.4 similar to synaptotagmin V UNQ564 11p15.4 MVAL564 PPFIBP2 11p15.5 PTPRF interacting protein, binding protein 2 (liprin beta 2) CYB5R2 11p15.4 cytochrome b5 reductase b5R.2 OVTN 11p15.4 oviductin protease LOC390091 11 similar to seven transmembrane helix receptor LOC390092 11 similar to olfactory receptor MOR204-2 LOC341278 11p15.4 similar to seven transmembrane helix receptor JCG3 11p15.4 olfactory receptor-like protein JCG3 JCG1 11p15.4 olfactory receptor-like protein JCG1 OR5E1P 11p15.5 olfactory receptor, family 5, subfamily E, member 1 pseudogene LOC390093 11 similar to Olfactory receptor 10A6 OR10A3 11p15.4 olfactory receptor, family 10, subfamily A, member 3 NALP10 11p15.4 NACHT, leucine rich repeat and PYD containing 10 EIF3S5 2p16.1 eukaryotic translation initiation factor 3, subunit 5 epsilon, 47kDa TUB 11p15.4 tubby homolog (mouse) RIC3 11p15.4 RIC3 protein LMO1 11p15.3 LIM domain only 1 (rhombotin 1) STK33 11p15.3 serine/threonine kinase 33 KIAA0298 11p15.5-p15.1 serine/threonine kinase 33 LOC283118 11p15.3 hypothetical LOC283118 RPL27A 11p15.5 ribosomal protein L27a ST5 11p15 suppression of tumorigenicity 5 C11orf17 11p15.3 chromosome 11 open reading frame 17 C11orf16 11p15.3 chromosome 11 open reading frame 16 ASCL3 11p15.3 achaete-scute complex (Drosophila) homolog-like 3 C11orf15 11p15.3 chromosome 11 open reading frame 15 NRIP3 11p15.3 nuclear receptor interacting protein 3 SCUBE2 11p15.3 signal peptide, CUB domain, EGF-like 2 FLJ46111 11p15.3 FLJ46111 protein RAB6IP1 11p15.3 RAB6 interacting protein 1 KIAA0033 11p15.3 KIAA0033 protein IPO7 11p15.3 importin 7 ZNF143 11p15.4-p15.3 zinc finger protein 143 (clone pHZ-1)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1274 - 156 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemprostate   
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    two N-terminal cysteine-rich LIM/double zinc finger motifs (LIM domains)
    HOMOLOGY
    interspecies ortholog to Lmo1, Mus musculus
    ortholog to Lmo1, Rattus norvegicus
    ortholog to LMO1, Pan troglodytes
    ortholog to lmo1, Danio rerio
    intraspecies paralog to LMO2, LMO3 and LMO4
    Homologene
    FAMILY
    CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    basic FUNCTION
  • having transcription factor activity
  • may be involved in gene regulation cells potentially by direct DNA binding or by binding to other transcription factors
  • intertwining LIM-only factor involved in protein-DNA oligomeric complexes
  • takes potentially part in a Hox paralogue 2-dependent network regulating anteroposterior and dorsoventral hindbrain patterning
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • TGF-beta, LMO1, possibly RUNX3, and GSDM form a regulatory pathway for directing the pit cells to apoptosis
  • a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    protein
  • leukemogenic bHLH proteins TAL1, TAL2 and LYL1 (
  • LIM-binding protein LDB1 (
  • embryonic neuronal-specific basic-helix-loop-helix protein, HEN1 (
  • LMO1 and SHOX2, are ARX targets (mutations in the ARX homeodomain disrupt repression of LMO1 and SHOX2, direct targets of ARX transcription repression)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    in acute lymphoblastic leukemia (T ALL)with translocation t(11;14)p15;q11),and a LMO1/LDB1 interaction, likely involved in tumorigenesis
    Susceptibility
  • to neuroblastoma
  • Variant & Polymorphism other common polymorphisms at the LMO1 locus are strongly associated with susceptibility to developing neuroblastoma (
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS