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FLASH GENE
Symbol LMAN2L contributors: mct - updated : 12-02-2019
HGNC name lectin, mannose-binding 2-like
HGNC id 19263
Corresponding disease
MRT52 mental retardation, autosomal recessive, 52
Location 2q11.2      Physical location : 97.371.668 - 97.405.813
Synonym name VIP36-like
Synonym symbol(s) VIPL, MGC11139, MRT52
DNA
TYPE functioning gene
STRUCTURE 34.16 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 2415 - 348 - 2008 18025080
9 - 2458 - 359 - 2008 18025080
6 - 2239 - 203 - 2008 18025080
7 - 2322 - 210 - 2008 18025080
8 - 2355 - 221 - 2008 18025080
7 - 2356 - 203 - 2008 18025080
8 - 2391 - 214 - 2008 18025080
8 - 2439 - 203 - 2008 18025080
10 - 2555 - 221 - 2008 18025080
8 - 2405 - 214 - 2008 18025080
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Digestiveintestinesmall intestine  lowly
 liver   moderately
Lymphoid/Immunespleen   highly
Nervousbrain   lowly
Respiratoryrespiratory tractlarynx  highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one leguminous lectin-like domain
  • a carbohydrate recognition domain (CRD), luminal carbohydrate recognition domain that binds to high-mannose-type oligosaccharides in a Ca2+-dependent manner
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Lman2l
    intraspecies homolog to LMAN2
    Homologene
    FAMILY
  • family of leguminous type (L-type) lectins
  • glycoprotein secretion chaperone family
  • CATEGORY chaperone/stress , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text
  • type 1 membrane protein
  • endoplasmic reticulum (ER) resident protein
  • basic FUNCTION
  • may function as an ER export (to Golgi) receptor for soluble glycoproteins
  • its sugar-binding activity was stronger at neutral pH, corresponding to the pH in the lumen of the ER, than under acidic conditions
  • LMAN2, LMAN2L, LMAN1, participate in the vectorial transport of glycoproteins via sugar-protein interactions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
    mannose binding
    protein interacting with LMAN1 (overexpression of LMAN2L redistribute LMAN1 to the ER, suggesting interaction and functional interplay between these two lectins)
  • LMAN1 may interact with LMAN2L in the ER, which may regulate the localization of LMAN1 inside cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MRT52
    Susceptibility
  • to bipolar disorder (BPD) and schizophrenia (SZ)
  • Variant & Polymorphism other
  • significant association between LMAN2L and risk of both BPD and SZ
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS