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FLASH GENE
Symbol LMAN2 contributors: mct - updated : 12-02-2019
HGNC name lectin, mannose-binding 2
HGNC id 16986
Location 5q35.3      Physical location : 176.758.563 - 176.778.885
Synonym name
  • chromosome 5 open reading frame 8
  • endoplasmic reticulum glycoprotein
  • vesicular integral-membrane protein VIP36
  • Synonym symbol(s) GP36B, VIP36, C5orf8, C19F2
    DNA
    TYPE functioning gene
    STRUCTURE 20.32 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    RNF44 5q35.3 ring finger protein 44 PC-LKC 5q35.3 protocadherin LKC KIAA1893 5q35.3 G protein-regulated inducer of neurite outgrowth 1 SNCB 5q35 synuclein, beta LOC253314 5q35.3 similar to eukaryotic translation initiation factor eIF4E-1 MGC14859 5q35.3 hypothetical protein MGC14859 LOC389348 5 LOC389348 KIAA1976 5q35.3 netrin receptor Unc5h1 HK3 5q35.2-q35.3 hexokinase 3 (white cell) RAP80 5q35.3 receptor associated protein 80 JAZ 5q35.3 double-stranded RNA-binding zinc finger protein JAZ FGFR4 5q35.3 fibroblast growth factor receptor 4 NSD1 5q35.1-q35.3 nuclear receptor binding SET domain protein 1 RAB24 5q35.3 RAB24, member RAS oncogene family PX19 5q35.3 px19-like protein MXD3 5q35.3 MAX dimerization protein 3 LMAN2 5q35 lectin, mannose-binding 2 RGS14 5q35.3 regulator of G-protein signalling 14 SLC34A1 5q35.1 solute carrier family 34 (sodium phosphate), member 1 LOC345456 5q35.3 similar to profilin 3 F12 5q35.1 coagulation factor XII (Hageman factor) GPRK6 5q35 G protein-coupled receptor kinase 6 MGC10772 5q35.3 hypothetical protein MGC10772 DBN1 5q35.3 drebrin 1 FLJ22570 5q35.3 Dok-like protein DDX41 5q35.3 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 HSGP25L2G 5q35.3 gp25L2 protein LOC391854 5 similar to Beta-1,4-galactosyltransferase 7 (Beta-1,4-GalTase 7) (Beta4Gal-T7) (b4Gal-T7) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7) ENIGMA 5q34-q35 similar to Beta-1,4-galactosyltransferase 7 (Beta-1,4-GalTase 7) (Beta4Gal-T7) (b4Gal-T7) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7) FLJ10404 5q35.3 hypothetical protein FLJ10404 B4GALT7 5q35.2-q35.3 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I) LOC202181 5q35.3 hypothetical protein LOC202181 NY-REN-7 5q35.3 NY-REN-7 antigen LOC391855 5 similar to olfactory receptor MOR126-1 LOC389349 5 hypothetical gene supported by NM_032361
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1853 - 356 - 2008 18025080
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
     intestinesmall intestine   
     liver   highly
     pancreas exocrine    
    Reproductivefemale systemovary   
     female systemuteruscervix  
    Skin/Tegumentskin    
    Urinarykidney   highly
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal signal sequence
  • one leguminous lectin-like domain, in its extracellular region
  • a lectin-type carbohydrate recognition domain
  • a C-terminal transmembrane domain, wirh tetrapeptide KRFY
  • conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    interspecies ortholog to rattus Lman2_predicted
    ortholog to murine Lman2
    intraspecies homolog to LMAN2L
    Homologene
    FAMILY family of leguminous type (L-type) lectins
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text
  • type 1 membrane protein
  • localizes to the Golgi apparatus and cycles early in the secretory pathway
  • localizes mainly to the ER and Golgi
  • basic FUNCTION
  • play a role as an intracellular lectin in the early secretory pathway
  • may retrieve misfolded glycoproteins back to the ER that have inadvertently escaped quality control in the ER
  • intracellular lectin that cycles between the endoplasmic reticulum (ER) and the Golgi apparatus, and is thought to act as a cargo receptor in the transport and sorting of glycoprotein
  • new role in the quality control of secretory proteins
  • shedding target and plays a role in phagocytosis in a shedding-dependent manner
  • regulates multiple steps of intracellular transport, including retrograde transport of immature glycoproteins from the Golgi to ER and phagocytosis of pathogens from the extracellular space to the endosome
  • LMAN2, LMAN2L, LMAN1, participate in the vectorial transport of glycoproteins via sugar-protein interactions
  • appears to be specifically required for the accumulation of GPRC5B in the Golgi complex and restriction of GPRC5B transport along the exosomal pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
  • Golgi-traversing pathway for exosomal release of the cargo protein GPRC5B in which CD2AP facilitates the entry and LMAN2 impedes the exit of the flux, respectively
  • a component
  • LMAN2/SERPINA1 complex localized to Golgi and endoplasmic reticulum (ER)
  • INTERACTION
    DNA
    RNA
    small molecule cofactor, other,
  • two Ca2+ binding
  • interacts with N-acetyl D-galactosamine and high-mannose type glycans
  • protein
  • interaction between LMAN2 and HSPA5, that is carbohydrate-independent
  • bound exclusively to the high-mannose form of SERPINA1 (function of LMAN2 in post-ER quality control of SERPINA1)
  • ADAM17 participates at least in part in the shedding of LMAN2
  • GUCY2C is the first identified receptor client of the lectin chaperone vesicular integral membrane protein, LMAN2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    tuberculosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene low expression of heterozygote genotype A/0 may be associated with protection against tuberculosis
    Marker
    Therapy target
    ANIMAL & CELL MODELS