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FLASH GENE

Symbol

LIPN

contributors: mct - updated : 03-11-2020

HGNC name	lipase, family member N
HGNC id	23452

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	LMLI4 lamellar ichthyosis 4
Location	10q23.31      Physical location : 90.521.162 - 90.537.997
Synonym symbol(s)	LI4, LIPL4, bA186O14.3, ARCI8

DNA

TYPE	functioning gene
STRUCTURE	16.84 kb     9 Exon(s)

MAPPING

cloned

Y

linked

Y

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001102469 9 - 1197 NP_001095939 - 398 - 2007 17562024

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Skin/Tegument skin       highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier lining epidermis   highly Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	LIPK, LIPM and LIPN genes are specifically expressed in epidermal cells and may play a role in differentiated keratinocyte cells in the body
	involved in triglyceride metabolism
	involvement of lipase N in the process of cornification

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

induced by

strongly induced during keratinocyte differentiation

ASSOCIATED DISORDERS

corresponding disease(s)

LMLI4

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS