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FLASH GENE
Symbol LIPI contributors: mlc - updated : 13-06-2007
HGNC name lipase, member I
HGNC id 18821
Location 21q11.2      Physical location : 15.481.136 - 15.579.254
Synonym name
  • lipid defect lipase
  • LPD lipase
  • membrane-associated phospholipase A1 beta
  • membrane-associated phosphatidic acid-selective phospholipase A1-beta
  • Synonym symbol(s) LPDL, PRED5, MAPA1B, LOC375108
    EC.number 3.1.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 98.00 kb     10 Exon(s)
    regulatory sequence Binding site
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - - - 481 - Staege (2004)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines testis cell lines (highly)
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Lpdl ( 71 p 100)
    Homologene
    FAMILY
  • AB hydrolase superfamily
  • lipase family
  • CATEGORY enzyme , secretory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • hydrolyzing specifically phosphatidic acid (PA) to produce lysophosphatidic acid (LPA)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with heparin with a high affinity
  • cell & other
    REGULATION
    inhibited by sodium vanadate
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    heterozygous C55Y in 2 Caucasians with moderate to severe hypertriglyceridemia (145750)
    Susceptibility to hypertriglyceridemia
    Variant & Polymorphism other DNA variant, namely 164G>A (C55Y), in hypertriglyceridemia
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS