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FLASH GENE
Symbol LIPF contributors: - updated : 24-06-2004
HGNC name lipase, gastric
HGNC id 6622
Location 10q23.33      Physical location : 90.424.093 - 90.438.572
Synonym symbol(s) HGL, HLAL
EC.number 3.1.1.3
DNA
TYPE functioning gene
STRUCTURE 14.00 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1365 45.2 398 - Bodmer
- initiation site 1365 - 392 - Bodmer
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal sequence
  • an alpha/beta hydrolase fold
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to Drosophila CG17099
    homolog to C.elegans F54F3.3 and ZK6.7
    homolog to rattus lingual lipase
    intraspecies homolog to LIPA
    Homologene
    FAMILY
  • abhydrolase superfamily
  • lipase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    text secreted by the fundic mucosa of the stomach
    basic FUNCTION
  • playing an important role in the digestion of dietary triglycerides in the gastrointestinal tract, especially in patients suffering from pancreatic lipase deficiencies
  • hydrolyzing the ester bonds of triglycerides under acidic pH conditions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS digestion
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    lipid catabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by the long chain free fatty acids generated by lipolysis
    Other acidic pH conditions
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS