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FLASH GENE
Symbol LIPE contributors: mct/npt/pgu - updated : 25-04-2012
HGNC name lipase, hormone-sensitive
HGNC id 6621
Location 19q13.2      Physical location : 42.905.666 - 42.931.578
Synonym name
  • hormone-sensitive lipase
  • hormone-sensitive lipase testicular isoform
  • Synonym symbol(s) HSL, LHS
    EC.number 3.1.1.79
    DNA
    TYPE functioning gene
    STRUCTURE 25.91 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    motif repetitive sequence
    MAPPING cloned Y linked Y status confirmed
    Map cen - RYR1 - D19S223 - D19S190 - D19S47 - D19S178 - D19S265E - D19S674E - LIPE - D19S872 - D19S420 - qter
    Authors UCSC (2009)
    Physical map
    LOC388544 19 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) MGC42718 19q13.31 hypothetical protein MGC42718 DMRTC2 19q13.31 DMRT-like family C2 RPS19 19q13.2 ribosomal protein S19 CD79A 19q13.2-q13.3 CD79A antigen (immunoglobulin-associated alpha) ARHGEF1 19q13,13 Rho guanine nucleotide exchange factor (GEF) 1 LOC390937 19 similar to Erf RABAC1 19q13.13-q13.2 Rab acceptor 1 (prenylated) ATP1A3 19q13.2 ATPase, Na+/K+ transporting, alpha 3 polypeptide GRIK5 19q13.2 glutamate receptor, ionotropic, kainate 5 FLJ22059 19q13.31 hypothetical protein FLJ22059 POU2F2 19q13.31 POU domain, class 2, transcription factor 2 DEDD2 19q13.31 POU domain, class 2, transcription factor 2 KIAA1951 GSK3A 19q13.2 glycogen synthase kinase 3 alpha ERF 19q13.1 Ets2 repressor factor CIC 19q13.2 capicua homolog (Drosophila) PAFAH1B3 19q13.1 platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa MGC70924 19q13.31 hypothetical LOC284338 FLJ90805 19q13.31 hypothetical protein FLJ90805 EGFL4 19q12 EGF-like-domain, multiple 4 SBP1 19q13.31 HBV pre-s2 binding protein 1 LOC84518 19q13.31 protein related with psoriasis LIPE 19q13.1-q13.2 lipase, hormone-sensitive UNQ473 19q13.31 DMC LOC388545 19 similar to Zinc finger protein 216 CEACAM1 19q13.2 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) CEACAMP2 19q13.2 carcinoembryonic antigen-related cell adhesion molecule pseudogene 2 CEACAM8 19q13.2 carcinoembryonic antigen-related cell adhesion molecule 8 CEACAMP1 19q13.2 carcinoembryonic antigen-related cell adhesion molecule pseudogene 1 LOC126341 PSG3 19q13.2 pregnancy specific beta-1-glycoprotein 3 LOC388546 19 similar to F19434_2 LOC390938 19 hypothetical gene supported by L36607; NM_002781
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 3300 84 775 adipose tissue 2002 11846402
    10 initiation site 3806 130 1076 testis, strictly expressed in haploid germ cells 2002 11846402
  • HSL tesl
  • encoded by a testis-specific exon and nine exons common to testis and adipocyte LIPE
  • - - 3300 84 775 testis, expressed in interstitial and tubular somatic cells as well as premeiotic germ cells 2002 11846402
  • possesses a unique 5 prime end that is transcribed from a novel testis-specific exon
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus   highly
    Nervousbrain   highly
    Reproductivefemale systembreastmammary gland highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  predominantly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • 'GDXG' lipolytic enzyme family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    text
  • translocation to the lipid droplet occurs by virtue of PLIN1 localization to the surface of lipid droplets and a physical interaction of LIPE occurring with sequences within the N-terminal region of PLIN1
  • basic FUNCTION
  • hydrolyzing stored triglycerides to free fatty acids
  • esterase and lipase, which are essential for spermatogenesis
  • playing an important role in regulating catecholamine-induced lipolysis
  • one of the mechanisms by which LIPE modulates adipose metabolism is potentially by providing intrinsic ligands or pro-ligands for PPARG
  • in adipose tissue, plays an important role in catecholamine-stimulated hydrolysis of stored lipids, thus mobilizing fatty acids
  • importance of LIPE for normal lipid metabolism in response to a high fat diet
  • triacylglycerol hydrolase and cholesterol esterase that is essential for male fertility
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
  • activated, phosphorylated LIPE translocates to the surface of the lipid droplet and forms a complex with multiple proteins facilitating efficient lipid hydrolysis
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with FABP4
  • physical interaction of LIPE with PLIN1 (can interact with an N-terminal region located between AAs 141 and 200 of PLIN1 as well as with a C-terminal region located between AAs 406 and 480)
  • NR1H3 binds to the proximal regions of the PLIN1 and LIPE promoters
  • transcription of LIPE is regulated by the PPARG/MRAP-mediated signaling pathway
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    decreased in the obese insulin-resistant state
    constitutional     --other  
    altered PNPLA2 and LIPE expression in skeletal muscle could promote diacylglycerol accumulation and disrupt insulin signaling and action
    constitutional     --over  
    LIPE or PNPLA2 overexpression resulted in increased triglyceride-specific hydrolase capacity, but only PNPLA2 overexpression increased whole cell lipolysis
    Susceptibility
  • to obesity and non insulin dependent diabetes
  • to male infertility
  • Variant & Polymorphism other
  • variants might be associated with a physiological effect on beta-adrenoceptor-mediated fat oxidation, at least in overweight-obese female subjects
  • genetic variation of LIPE may be a risk factor for male infertility
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    pharmacological inhibition of lipases LIPE and PNPLA2) may represent a powerful strategy to avoid the devastating condition of cachexia in response to cancer or other chronic diseases
    ANIMAL & CELL MODELS
    Hsl null mice have been shown to be resistant to diet-induced obesity