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FLASH GENE
Symbol LIN7C contributors: mct - updated : 09-06-2009
HGNC name lin-7 homolog C (C. elegans)
HGNC id 17789
Location 11p14.1      Physical location : 27.515.970 - 27.528.326
Synonym name
  • LIN-7 protein 3
  • likely ortholog of mouse LIN-7C
  • mammalian LIN-7 protein 3
  • Veli-3 protein
  • Synonym symbol(s) VELI3, LIN-7C, MALS-3, LIN-7-C, FLJ11215, MALS3
    DNA
    TYPE functioning gene
    STRUCTURE 12.36 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 4866 22 197 - 1998 9753324
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Nervousbrainhindbraincerebellum  
     braindiencephalonhypothalamus  
     braindiencephalonthalamusnuclei 
    Olfactoryolfactory bulb    
    Reproductivefemale systemuterus  highly
    Respiratoryrespiratory tractlarynx  highly
     respiratory tracttrachea  highly
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    Text
  • in the developing cerebral cortex
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a PDZ domain
  • mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to C.elegans Lin7
    Homologene
    FAMILY
  • lin-7 family
  • p55 Stardust family of membrane-associated guanylate kinase (MAGUK) proteins
  • CATEGORY regulatory , structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular,cytoplasm
    text
  • localizing in synapses
  • localized to the apical domain of neural progenitor cells
  • colocalizes with adaptor proteins DLG4, ANO2, and MPP4 at the ribbon synapses
  • basic FUNCTION
  • involved in regulation of synaptic function and synapse assembly
  • plays a role in maintaining apicobasal polarity and is required for normal neurogenesis in the developing cortex
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS nervous system
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
  • heterotrimerizing with CASK, MINT1
  • dimer of MPP7 with LIN7A or LIN7C associates with DLG1 through an interaction requiring the amino-terminal L27 domain of MPP7
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to HTR2C
  • DLG4/LIN7C assembly and maintenance at synaptic membranes is coordinated by MPP4
  • interacting with CASK and DLG1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in oral squamous cell carcinoma (OSCC) metastasis (Onda 2007)
    constitutional        
    of either CDH2 or LIN7C disrupts neural tube formation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS