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FLASH GENE
Symbol LIN7C contributors: mct - updated : 09-06-2009
HGNC name lin-7 homolog C (C. elegans)
HGNC id 17789
Location 11p14.1      Physical location : 27.515.970 - 27.528.326
Synonym name
  • LIN-7 protein 3
  • likely ortholog of mouse LIN-7C
  • mammalian LIN-7 protein 3
  • Veli-3 protein
  • Synonym symbol(s) VELI3, LIN-7C, MALS-3, LIN-7-C, FLJ11215, MALS3
    DNA
    TYPE functioning gene
    STRUCTURE 12.36 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC203859 11p15.1 hypothetical protein LOC203859 SLC17A6 11p14.3 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6 FANCF 11p15 Fanconi anemia, complementation group F GAS2 11p15.2-p14.3 growth arrest-specific 2 LOC196188 11p14.3 similar to ribosomal protein S2 LOC341002 11p14.3 similar to dJ568F9.1 (zinc finger protein 133 (clone pHZ-13)) LOC338645 11p14.3 hypothetical protein LOC338645 LOC390103 11 similar to amyloid beta precursor protein-binding protein 1; amyloid protein-binding protein 1 TMEM16C 11p14.3 transmembrane protein 16C MUC15 11p14.3 mucin 15 MGC52019 11p14.3 hypothetical protein MGC52019 LOC387758 11 similar to RIKEN cDNA 1110018M03 BBOX1 11p14.1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 NY-REN-41 11p14.2 NY-REN-41 antigen GPR48 11p14-p13 G protein-coupled receptor 48 LIN7C 11p14 lin-7 homolog C (C. elegans) LOC283114 11p14.2 similar to 40S ribosomal protein S25 BDNF 11p14 brain-derived neurotrophic factor LOC159770 11p14.1 chromobox homolog 3 gamma pseudogene HSPCAL3 11p14.2-p14.1 heat shock 90kDa protein 1, alpha-like 3 DKFZP434G2226 11p14.1 kinesin family member 18A FLJ33979 11p14.1 hypothetical protein FLJ33979 LOC390104 11 similar to eukaryotic translation elongation factor 1 alpha 1-like 14 KCNA4 11p14.1 potassium voltage-gated channel, shaker-related subfamily, member 4 FSHB 11p13 follicle stimulating hormone, beta polypeptide FLJ38968 11p14.1 hypothetical protein FLJ38968 C11orf8 11p13 chromosome 11 open reading frame 8 LOC387759 11 LOC387759 FLJ46154 11p14.1 FLJ46154 protein LOC341019 HCP25 11p13 cytochrome c, somatic pseudogene LOC120526 11p14.1 hypothetical protein LOC120526 FLJ25059 11p14.1 hypothetical protein FLJ25059 ELP4 11p13 elongation protein 4 homolog (S. cerevisiae) PAX6 11p13 paired box gene 6 (aniridia, keratitis) RCN1 11p13 reticulocalbin 1, EF-hand calcium binding domain LOC390105 11 similar to RIKEN cDNA 0610012H03 WT1 11p13 Wilms tumor 1 WIT-1 11p13 Wilms tumor associated protein LOC387760 11 LOC387760 GA17 11p13 LOC387760 RPL34P2 11p13 ribosomal protein L34 pseudogene 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 4866 22 197 - 1998 9753324
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Nervousbrainhindbraincerebellum  
     braindiencephalonhypothalamus  
     braindiencephalonthalamusnuclei 
    Olfactoryolfactory bulb    
    Reproductivefemale systemuterus  highly
    Respiratoryrespiratory tractlarynx  highly
     respiratory tracttrachea  highly
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    Text
  • in the developing cerebral cortex
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a PDZ domain
  • mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to C.elegans Lin7
    Homologene
    FAMILY
  • lin-7 family
  • p55 Stardust family of membrane-associated guanylate kinase (MAGUK) proteins
  • CATEGORY regulatory , structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular,cytoplasm
    text
  • localizing in synapses
  • localized to the apical domain of neural progenitor cells
  • colocalizes with adaptor proteins DLG4, ANO2, and MPP4 at the ribbon synapses
  • basic FUNCTION
  • involved in regulation of synaptic function and synapse assembly
  • plays a role in maintaining apicobasal polarity and is required for normal neurogenesis in the developing cortex
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS nervous system
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
  • heterotrimerizing with CASK, MINT1
  • dimer of MPP7 with LIN7A or LIN7C associates with DLG1 through an interaction requiring the amino-terminal L27 domain of MPP7
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to HTR2C
  • DLG4/LIN7C assembly and maintenance at synaptic membranes is coordinated by MPP4
  • interacting with CASK and DLG1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in oral squamous cell carcinoma (OSCC) metastasis (Onda 2007)
    constitutional        
    of either CDH2 or LIN7C disrupts neural tube formation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS