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Symbol LIN28B contributors: mct/ - updated : 09-11-2017
HGNC name lin-28 homolog B (C. elegans)
HGNC id 32207
Location 6q16.3      Physical location : 105.404.922 - 105.531.206
Synonym name protein lin-28 homolog B
Synonym symbol(s) FLJ16517, CSDD2, Lin-28.2
TYPE functioning gene
SPECIAL FEATURE head to head
STRUCTURE 126.28 kb     4 Exon(s)
MAPPING cloned Y linked N status provisional
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 5504 27 250 - 2006 16971064
Type restricted
   expressed in (based on citations)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Hearing/Equilibriumearinnercochlea predominantly
Reproductivefemale systemplacenta  moderately
 male systemtestis  moderately
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly Homo sapiens
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneT cell Homo sapiensFetal
cell lineage
cell lines
physiological period fetal
Text LIN28B may be necessary during early development
  • two CCHC-type zinc fingers
  • a cold-shock DNA-binging (CSD) domain
  • C-terminal unique ~50 amino acid stretch of LIN28B is essential for TRIM71 interactions and subsequent polyubiquitination
    interspecies homolog to murine Lin28b (86.64 pc)
    intraspecies paralog to LIN28A
  • lin-28 family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • may play a role in developmental timing
  • may regulate genes involved in the execution of stage-specific developmental fates of diverse somatic cell types
  • possible mRNA chaperone
  • may be necessary during early development
  • up-regulation in HCC tissues and cell lines
  • important roles during hepatocarcinogenesis
  • playing a critical role during development and tumorigenesis
  • its activation is necessary and sufficient for MYC-mediated let-7 repression
  • having a critical role in the regulation of human growth
  • regulates tumor formation and invasion in hepatocellular carcinoma through coordinated repression of the let-7/mir-98 family and induction of multiple oncogenic pathways (
  • having a function in promoting colon tumor pathogenesis, especially metastasis
  • RNA-binding protein that inhibits biogenesis of let-7 microRNAs, and LIN28B post-transcriptionally regulates LGR5 and PROM1 through a let-7-independent mechanism
  • LIN28A and LIN28B are important and essential regulators of glucose homeostasis
  • regulates developmental processes by modulating microRNAs (miRNAs) of the MIRLET7 family
  • LIN28B expression regulates HbF levels and causes adult human erythroblasts to differentiate with a more fetal-like phenotype
  • LIN28A, LIN28B are novel regulators of innate immune function and new proteins of interest in Mast cells (MCs) disease
  • LIN28A and LIN28B have overlapping functions in temporally regulating neural progenitor cells (NPCs) proliferation during early brain development
  • RNA-binding protein LIN28B is likely a critical regulator of developmental timing in the cochlea
  • LIN28A and LIN28B play critical roles in embryonic development, tumorigenesis, and pluripotency
  • in human fibroblasts, LIN28B is activated early during reprogramming, while LIN28A is activated later during the transition to bona fide induced pluripotent stem cells (iPSCs)
  • LIN28A and LIN28B play cooperative roles in regulating reprogramming, naive/primed pluripotency, and stem cell metabolism
  • increased fetal Treg differentiation is mediated by the RNA-binding protein LIN28B, which is overexpressed in fetal T cells as compared with adult cells
  • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, transcription, regulation
    a component
  • unexpected roles for the LIN28A/LIN28B/MIRLET7A1 pathway in regulating metabolism
  • LIN28B–MIRLET7A1–MYCN signaling blocked differentiation of normal neuroblasts and neuroblastoma cells
  • LIN28B–MIRLET7A1 axis acts as a critical driver of PNS myelination, in particular by regulating myelination onset, identifying this pathway also as a potential therapeutic target in demyelinating diseases
    DNA binding
    RNA bindng
    small molecule
  • Zn2+
  • protein
  • promote malignancy by inhibiting MIRLET7A1 biogenesis
  • in cells, TRIM71 negatively regulates LIN28B protein stability by catalyzing polyubiquitination
  • LIN28B promotes fetal B lymphopoiesis through the transcription factor ARID3A
  • LIN28 binds to mRNAs of proteins important for oxidative phosphorylation and modulates protein abundance
  • regulates fetal regulatory T cell differentiation through modulation of TGFB1 signaling
  • cell & other
    Other a possible target of let-7 miRNA
    LIN28B protein level is regulated via ubiquitin-mediated proteasomal degradation
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinoma, and its possibleregulation by microRNA implicate a critical role ofLIN28B during tumorigenesis and suggest a possible novel mechanism
    tumoral     --over  
    in primary tumors and cancer cell lines and overexpression is linked to repression of let-7 family miRNAs and derepression of let-7 targets
    tumoral     --over  
    in colon tumors, and overexpression correlates with reduced patient survival and increased probability of tumor recurrence
    tumoral     --other  
    deregulation of MYCN, LIN28B and MIRLET7 in a molecular subtype of aggressive high-grade serous ovarian cancers
    tumoral     --over  
    extensive overexpression in high-risk neuroblastoma compared to several other tumor entities and normal tissues
    tumoral     --over  
    in colon cancer tissue compared to normal mucosa, and its overexpression correlated with reduced patient survival and increased tumour recurrence
  • to epithelial ovarian cancer
  • to neuroblastoma
  • Variant & Polymorphism other
  • variants in LIN28B and possibly other miRNA biogenesis genes may influence epithelial ovarian cancer susceptibility
  • common variants in HACE1 and LIN28B influence neuroblastoma susceptibility
  • Candidate gene
    Marker LIN28B may serve as a diagnostic tool for colon cancer
    Therapy target
    therapeutic target for colon cancer
    antagonizing LIN28B function in tumors that overexpress these genes may provide a means to reactivate the expression of let-7 family tumor suppressors, and may thus be therapeutically beneficial
    is a potential therapeutic target of gastric adenocarcinoma (GAC) patients