Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

LIN28B

contributors: mct/ - updated : 09-11-2017

HGNC name	lin-28 homolog B (C. elegans)
HGNC id	32207

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6q16.3      Physical location : 105.404.922 - 105.531.206
Synonym name	protein lin-28 homolog B
Synonym symbol(s)	FLJ16517, CSDD2, Lin-28.2

DNA

TYPE	functioning gene
SPECIAL FEATURE	head to head
STRUCTURE	126.28 kb     4 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001004317 4 - 5504 NP_001004317 27 250 - 2006 16971064

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Hearing/Equilibrium ear inner cochlea   predominantly Nervous nerve         Reproductive female system placenta     moderately   male system testis     moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune T cell Homo sapiens Fetal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	LIN28B may be necessary during early development

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two CCHC-type zinc fingers
	a cold-shock DNA-binging (CSD) domain
	C-terminal unique ~50 amino acid stretch of LIN28B is essential for TRIM71 interactions and subsequent polyubiquitination

HOMOLOGY

interspecies

homolog to murine Lin28b (86.64 pc)

intraspecies

paralog to LIN28A

Homologene

FAMILY

lin-28 family

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleolus

basic FUNCTION	may play a role in developmental timing
	may regulate genes involved in the execution of stage-specific developmental fates of diverse somatic cell types
	possible mRNA chaperone
	may be necessary during early development
	up-regulation in HCC tissues and cell lines
	important roles during hepatocarcinogenesis
	playing a critical role during development and tumorigenesis
	its activation is necessary and sufficient for MYC-mediated let-7 repression
	having a critical role in the regulation of human growth
	regulates tumor formation and invasion in hepatocellular carcinoma through coordinated repression of the let-7/mir-98 family and induction of multiple oncogenic pathways (
	having a function in promoting colon tumor pathogenesis, especially metastasis
	RNA-binding protein that inhibits biogenesis of let-7 microRNAs, and LIN28B post-transcriptionally regulates LGR5 and PROM1 through a let-7-independent mechanism
	LIN28A and LIN28B are important and essential regulators of glucose homeostasis
	regulates developmental processes by modulating microRNAs (miRNAs) of the MIRLET7 family
	LIN28B expression regulates HbF levels and causes adult human erythroblasts to differentiate with a more fetal-like phenotype
	LIN28A, LIN28B are novel regulators of innate immune function and new proteins of interest in Mast cells (MCs) disease
	LIN28A and LIN28B have overlapping functions in temporally regulating neural progenitor cells (NPCs) proliferation during early brain development
	RNA-binding protein LIN28B is likely a critical regulator of developmental timing in the cochlea
	LIN28A and LIN28B play critical roles in embryonic development, tumorigenesis, and pluripotency
	in human fibroblasts, LIN28B is activated early during reprogramming, while LIN28A is activated later during the transition to bona fide induced pluripotent stem cells (iPSCs)
	LIN28A and LIN28B play cooperative roles in regulating reprogramming, naive/primed pluripotency, and stem cell metabolism
	increased fetal Treg differentiation is mediated by the RNA-binding protein LIN28B, which is overexpressed in fetal T cells as compared with adult cells

CELLULAR PROCESS	cell life, proliferation/growth
	nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	unexpected roles for the LIN28A/LIN28B/MIRLET7A1 pathway in regulating metabolism
	LIN28B–MIRLET7A1–MYCN signaling blocked differentiation of normal neuroblasts and neuroblastoma cells
	LIN28B–MIRLET7A1 axis acts as a critical driver of PNS myelination, in particular by regulating myelination onset, identifying this pathway also as a potential therapeutic target in demyelinating diseases

INTERACTION

DNA

binding

RNA

bindng

small molecule
	Zn2+

protein	promote malignancy by inhibiting MIRLET7A1 biogenesis
	in cells, TRIM71 negatively regulates LIN28B protein stability by catalyzing polyubiquitination
	LIN28B promotes fetal B lymphopoiesis through the transcription factor ARID3A
	LIN28 binds to mRNAs of proteins important for oxidative phosphorylation and modulates protein abundance
	regulates fetal regulatory T cell differentiation through modulation of TGFB1 signaling

cell & other

REGULATION

Other	a possible target of let-7 miRNA
	LIN28B protein level is regulated via ubiquitin-mediated proteasomal degradation

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in hepatocellular carcinoma, and its possibleregulation by microRNA implicate a critical role ofLIN28B during tumorigenesis and suggest a possible novel mechanism tumoral     --over   in primary tumors and cancer cell lines and overexpression is linked to repression of let-7 family miRNAs and derepression of let-7 targets tumoral     --over   in colon tumors, and overexpression correlates with reduced patient survival and increased probability of tumor recurrence tumoral     --other   deregulation of MYCN, LIN28B and MIRLET7 in a molecular subtype of aggressive high-grade serous ovarian cancers tumoral     --over   extensive overexpression in high-risk neuroblastoma compared to several other tumor entities and normal tissues tumoral     --over   in colon cancer tissue compared to normal mucosa, and its overexpression correlated with reduced patient survival and increased tumour recurrence

Susceptibility

to epithelial ovarian cancer to neuroblastoma

Variant & Polymorphism other	variants in LIN28B and possibly other miRNA biogenesis genes may influence epithelial ovarian cancer susceptibility
	common variants in HACE1 and LIN28B influence neuroblastoma susceptibility

Candidate gene
Marker	LIN28B may serve as a diagnostic tool for colon cancer
Therapy target
	System Type Disorder Pubmed cancer digestive colon therapeutic target for colon cancer cancer     antagonizing LIN28B function in tumors that overexpress these genes may provide a means to reactivate the expression of let-7 family tumor suppressors, and may thus be therapeutically beneficial cancer digestive stomach is a potential therapeutic target of gastric adenocarcinoma (GAC) patients

ANIMAL & CELL MODELS