SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,cytosolic,granule
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| intracellular,nucleus,nucleolus
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| abundant in undifferentiated cells |
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accumulates in the nucleus, suggesting that it normally shuttles from nucleus to cytoplasm bound to RNA |
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is localized to the periendoplasmic reticulum (ER) area and inhibits translation of mRNAs that are destined for the ER, reducing the synthesis of transmembrane proteins, ER or Golgi lumen proteins, and secretory proteins |
basic FUNCTION
| has an important developmental role |
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involved in translation or RNA processing |
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influences the translation or stability of specific mRNAs during differentiation |
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may be a natural target for microRNA mediated regulation |
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act mainly in the cytoplasm by inducing uridylation of precursor let-7 (pre-let-7) at its 3prime end |
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Lin28-mediated downregulation of let-7 may play a key role in development, stem cell programming, and tumorigenesis |
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negative regulator of let-7 microRNA processing, essential for proper primordial germ cells development |
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mediates post-transcriptional regulation of POU5F1 expression in embryonic stem cells by direct binding to POU5F1 mRNA |
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in mice may coordinate the rapid growth and metabolism of early embryogenesis and in turn delay the phenotypes associated with adulthood |
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LIN28A and LIN28B are important and essential regulators of glucose homeostasis |
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is both necessary and sufficient to influence glucose metabolism through the regulation of insulin-PI3K-MTOR signaling |
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LIN28A/LIN28B may regulate metabolism through direct mRNA-binding as well as MIRLET7A1 targets |
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important roles for this protein in the maintenance of the germline stem cell state and the regulation of microRNA activity in the developing human ovary |
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is reactivated in about 10p100 of epithelial tumors and promotes cell cycle progression by regulation of both mRNA translation (let-7-independent) and miRNA biogenesis (let-7-dependent) |
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is a conserved RNA-binding protein implicated in pluripotency, reprogramming, and oncogenesis |
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important regulatory functions of LIN28A via direct mRNA interactions |
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plays important roles in development, stem cell maintenance, oncogenesis and metabolism |
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LIN28A-dependent stimulation of translation of target mRNAs may, in part, serve to compensate for their intrinsic instability, thereby ensuring optimal levels of expression of genes critical for cell viability, metabolism and pluripotency |
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role of LIN28A as a global suppressor of genes in the secretory pathway |
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is an essential factor of nucleologenesis during early embryonic development |
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role for LIN28A in prostate carcinoma development and activation of the AR axis |
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has a functional role in regulating trophoblast differentiation and function |
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RNA-binding protein expressed during embryogenesis, playing roles in development, pluripotency, and metabolism |
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enhances tissue repair in some adult tissues by reprogramming cellular bioenergetics |
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LIN28A, LIN28B are novel regulators of innate immune function and new proteins of interest in Mast cells (MCs) disease |
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LIN28A and LIN28B have overlapping functions in temporally regulating neural progenitor cells (NPCs) proliferation during early brain development |
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LIN28A and LIN28B play critical roles in embryonic development, tumorigenesis, and pluripotency |
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in human fibroblasts, LIN28B is activated early during reprogramming, while LIN28A is activated later during the transition to bona fide induced pluripotent stem cells (iPSCs) |