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FLASH GENE
Symbol LIMS1 contributors: mct/npt/shn/pgu - updated : 06-06-2011
HGNC name LIM and senescent cell antigen-like domains 1
HGNC id 6616
Location 2q12.3      Physical location : 109.150.856 - 109.303.697
Synonym name
  • particularly interesting new Cys-His protein 1
  • renal carcinoma antigen NY-REN-48
  • LIM and senescent cell antigen-like-containing domain protein 1
  • Synonym symbol(s) PINCH, PINCH1
    DNA
    TYPE functioning gene
    STRUCTURE 152.85 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D2S340 - D2S1889 - LIMS1 - D2S1893 - D2S1891 - qter
    Physical map
    LOC391415 2 similar to ribosomal protein S21; 40S ribosomal protein S21 LOC391416 2 similar to hypothetical protein MGC4614 LOC389016 2 similar to RAN-binding protein 2-like 1 isoform 1; sperm membrane protein BS-63; RAN-binding protein 2-like 1 LOC391417 2 similar to anaphase-promoting complex 1 (meiotic checkpoint regulator) CD8B2 2q12 CD8 antigen, beta polypeptide 2, pseudogene (p37) LOC389017 2 similar to Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor 1 A-1) (eEF1A-1) (Elongation factor Tu) (EF-Tu) LOC389018 2 similar to Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor 1 A-1) (eEF1A-1) (Elongation factor Tu) (EF-Tu) ST6GalII 2q11.2-q12.1 beta-galactoside alpha-2,6-sialyltransferase II LOC339819 2q12.3 similar to protein phosphatase 1, regulatory (inhibitor) subunit 2 DKFZp686P0288 2q12.3 similar to Ran-binding protein 2 SLC5A7 2q12 solute carrier family 5 (choline transporter), member 7 LOC391418 2 similar to phenol sulfotransferase SULT1C1 2q11.1-q11.2 sulfotransferase family, cytosolic, 1C, member 1 LOC391419 2 similar to sulfotransferase 1C SULT1C2 2q11.2 sulfotransferase family, cytosolic, 1C, member 2 GCC2 2q12-q13 GRIP and coiled-coil domain-containing 2 MGC10701 2q12.3 hypothetical protein MGC10701 LIMS1 2q12 LIM and senescent cell antigen-like domains 1 LOC391420 2 similar to 60S ribosomal protein L10 (QM protein) (Tumor suppressor QM) (Laminin receptor homolog) RANBP2 2q11-q13 RAN binding protein 2 FLJ32745 2q12.3 hypothetical protein FLJ32745 EDAR 2q11-q13 ectodysplasin 1, anhidrotic receptor LOC389019 2 LOC389019 FLJ20019 2q13 hypothetical protein FLJ20019 FLJ00204 2q13 FLJ00204 protein SEPT10 2q13 septin 10 FLJ21870 2q13 hypothetical protein FLJ21870 LOC391421 2 similar to Ribosome biogenesis protein BMS1 homolog LOC391422 2 similar to ribosomal protein L22 RANBP2L1 2q12.3 RAN binding protein 2-like 1 LOC339692 2q13 hypothetical protein LOC339692 GPAA1P1 2q12-q14 glycosylphosphatidylinositol anchor attachment 1 pseudogene 1 LOC391423 2 similar to zinc finger protein 499 LOC343938 2q13 similar to zinc finger protein BENE 2q13 BENE protein NPHP1 2q12-q13 nephronophthisis 1 (juvenile) LOC205251 2q13 hypothetical protein LOC205251 FLJ38359 2q13 hypothetical protein FLJ38359 LOC96626 2q14-q21 pinch-2 LOC391424 2 similar to ribosomal protein L22
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 splicing 1559 - 325 - -
    10 splicing 4690 - 387 - -
    10 splicing 4460 - 362 - -
    10 splicing 4339 - 329 - -
    10 splicing 4407 - 325 - -
    10 splicing 4438 - 337 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly Homo sapiens
    Digestiveintestinesmall intestine  lowly Homo sapiens
     liver   lowly Homo sapiens
    Lymphoid/Immunespleen   lowly Homo sapiens
     thymus   lowly Homo sapiens
    Nervousbraindiencephalonamygdala lowly Homo sapiens
     brainbasal nucleicorpus callosum lowly Homo sapiens
     braindiencephalonhypothalamus lowly Homo sapiens
     braindiencephalonthalamusnucleilowly Homo sapiens
     brainlimbic systemhippocampus lowly Homo sapiens
     brainmidbrainsubstantia nigra moderately Homo sapiens
     brainbasal nucleicaudate nucleus lowly Homo sapiens
    Reproductivefemale systemovary  moderately Homo sapiens
     female systemplacenta  lowly Homo sapiens
     male systemtestis  lowly Homo sapiens
     male systemprostate  lowly Homo sapiens
    Respiratorylung   lowly Homo sapiens
    Urinarykidney   moderately Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Muscularstriatumskeletal   Homo sapiens
    Muscularstriatumcardiacmyocardiumhighly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • five LIM domains, LIM domain 1 required for its interaction with ILK or double zinc fingers and required for the localization to cell adhesion complexes
  • zinc binding domain
  • HOMOLOGY
    interspecies ortholog to Lims1, Mus musculus
    ortholog to Lims1, Rattus norvegicus
    ortholog to lims1, Danio rerio
    ortholog to LIMS1, Pan troglodytes
    Homologene
    FAMILY
  • LIM domain protein family
  • CATEGORY adaptor , adhesion , signaling
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane,junction,adherens
        intracellular
    intracellular,cytoplasm
    text located at cell-extracellular matrix attachment sites known as cell adhesion complexes
    basic FUNCTION
  • involved in integrin-mediated cell adhesion or spreading
  • involved in integrin function, actin organization, cell-cell adhesion
  • cysteine-histidine rich protein, an adapter protein involved in integrin and growth factor signaling
  • essential focal adhesion protein with multiple functions including regulation of the integrin-linked kinase (ILK) level, cell shape, and survival signaling
  • functioning as a molecular platform for coupling and uncoupling diverse cellular processes via overlapping but yet distinct domain interactions
  • five LIM domain protein involved in the regulation of integrin-mediated cell adhesion
  • LIMS1, and LIMS2 share overlapping functions and operate dependently and independently of their subcellular localization
  • promotes activating phosphorylation of Src family kinase and ERK1/2
  • plays an essential role in neural crest development, perhaps in part through transforming growth factor-beta signaling
  • required for the formation of integrin based adhesion structures
  • adaptor protein that binds to the integrin-linked kinase (ILK), an intracellular serine/threonine protein kinase that plays a critical role in mediating tubular epithelial-to-mesenchymal transition (EMT)
  • through its interaction with ILK, plays an important role in regulating TGF-beta1-mediated EMT
  • LIM-only adaptor (the particularly interesting cysteine- and histidine-rich protein) playing a pivotal role in the assembly of focal adhesions (FAs)
  • 5 LIM domain-only adaptor protein that function as key components of the integrin signaling pathway and play crucial roles in multiple cellular processes
  • essential roles in myocardial growth, maturation, remodeling, and function
  • LIM1 domain of PINCH-1 is sufficient for cell attachment and the C-terminal region of PINCH-1 plays a pivotal role in cell spreading
  • plays an important role in regulating the integrin-mediated cell adhesion, migration and epithelial-mesenchymal transition
  • acts as a transcriptional regulator through controlling specific gene expression
  • regulate cardiac contractility by modulating integrin-linked kinase-protein kinase B signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NCK adaptor protein 2, NCK2 (
  • integrin-linked kinase, ILK (
  • PINCH, integrin-linked kinase (ILK) and calponin homology-containing ILK-binding protein (CH-ILKBP) form a ternary complex that playing crucial roles at cell-extracellular matrix adhesion sites (
  • thymosin beta 4 X-linked, TMSB4X (
  • Ras suppressor protein 1, RSU1 (
  • heterotrimeric complex between integrin-linked kinase , PINCH, and parvin (
  • LIMS1 interacted with WT1, a nuclear transcription factor that is essential for regulating podocyte-specific gene expression in adult kidney
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in the stroma of oral squamous cell carcinoma predicting nodal metastasis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target could be a potential future therapeutic target to prevent progression of renal disease
    ANIMAL & CELL MODELS