SUBCELLULAR LOCALIZATION
| intracellular
|
| intracellular,cytoplasm,organelle,Golgi
|
| intracellular,cytoplasm,cytosolic
|
| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
|
| intracellular,nucleus
|
text
| diffusely localized in the cytoplasm during interphase, redistributed to the mitotic spindle, and finally to the spindle midzone during anaphase to telophase |
|
isoform 2a is cytoplasmic or nuclear whereas isoform 2b is mainly cytoplasmic |
|
function as a shuttle between the cytoplasm and nucleus in endothelial cells |
basic FUNCTION
| cysteine-rich structures containing 2 zinc fingers, displaying serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) |
|
mediating with cofilin, actin cytoskeleton reorganization induced by transforming growth factor-beta |
|
regulate actin cytoskeletal reorganization through phosphorylating and inactivating cofilin, an actin-depolymerizing factor of actin filaments |
|
may associate with gamma-tubulin and play a role in mitotic spindle assembly (Chakrabarti 2007) |
|
important for normal mitotic spindle formation and altered LIMK2 expression mediates sensitivity to microtubule destabilizing agents |
|
LIM domain-containing protein kinase which regulates actin polymerization thorough phosphorylation of the actin depolymerizing factor cofilin |
|
acts through TPPP in the regulation of astral microtubule organization, whereas both LIMK1 and LIMK2 affect centrosome focusing |
|
LIMK2 inhibition or ablation is an alternative approach for modulating Aurora A deregulation in cancer |
|
key downstream effector of Rho GTPase-induced changes in cytoskeletal organization |
|
LIMK2 activity is required for keratinocyte migration in the developing eyelid |
|
may participate in the mitotic block induced by microtubule-targeted drugs through regulation of the microtubule network (pMID: 23991158) |