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FLASH GENE
Symbol LIME1 contributors: mct - updated : 03-04-2023
HGNC name Lck interacting transmembrane adaptor 1
HGNC id 26016
Location 20q13.33      Physical location : 62.367.977 - 62.370.459
Synonym name
  • Lck-interacting membrane protein
  • Lck-interacting molecule
    • Synonym symbol(s) FLJ20406, dJ583P15.4, LIME, RP4-583P15.5
    DNA
    TYPE functioning gene
    STRUCTURE 3.40 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1559 - 176 - 2012 22395814
    6 - 1157 - 295 - 2012 22395814
    6 - 1122 - 176 - 2012 22395814
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticplasma  highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell Homo sapiens
    Lymphoid/ImmuneT cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • transmembrane adaptor protein mediating TCR-dependent T cell activation
  • LIME is a transmembrane adaptor protein linking TCR stimulation to IS formation and integrin activation through activation of VAV1
  • raft-associated transmembrane protein expressed predominantly in T and B lymphocytes
  • is a critical regulator of inflammatory chemokine-mediated signaling and the subsequent migration of effector T cells to inflammatory sites
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to Attention-deficit/hyperactivity disorder (ADHD)
  • to multiple sclerosis
    • Variant & Polymorphism other
  • DNA methylation of two CpG sites in LIME1 is associated with attention deficits in children
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS