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FLASH GENE
Symbol LILRB5 contributors: npt/ - updated : 07-12-2005
HGNC name leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5
HGNC id 6609
Location 19q13.42      Physical location : 54.754.270 - 54.761.167
Synonym name
  • leukocyte immunoglobulin-like receptor 8
  • CD85 antigen-like family member C
  • Synonym symbol(s) LIR8, LIR-8, CD85C
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 6.90 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Map cen - D19S418 - PTPRH - LILRB5 - RPL28 - D19S210 - D19S214 - D19S218 - D19S890 - RPS5 - RPL13A - qter
    Authors Gene Map (98)
    Text see FLNKR@
    Physical map
    LOC91663 PRKCG 19q13.4 protein kinase C, gamma CACNG7 19q13.4 calcium channel, voltage-dependent, gamma subunit 7 CACNG8 19q13.4 calcium channel, voltage-dependent, gamma subunit 8 CACNG6 19q13.4 calcium channel, voltage-dependent, gamma subunit 6 UNQ3033 19q13.42 LAIR hlog OSCAR 19q13.42 osteoclast-associated receptor NDUFA3 19q13.42 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa TFPT 19q13.4 TCF3 (E2A) fusion partner (in childhood Leukemia) PRPF31 19q13.42 PRP31 pre-mRNA processing factor 31 homolog (yeast) CNOT3 19q13.4 CCR4-NOT transcription complex, subunit 3 LENG1 19q13.4 leukocyte receptor cluster (LRC) member 1 TMC4 19q13.42 transmembrane channel-like 4 LENG4 19q13.4 transmembrane channel-like 4 LENG5 19q13.4 leukocyte receptor cluster (LRC) member 5 RPS9 19q13.4 ribosomal protein S9 LILRB3 19q13.4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 ILT8 19q13.4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 6 LILRB5 19q13.4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5 LILRB2 19q13.4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 LOC390971 19 similar to YME1-like 1; ATP-dependent metalloprotease FtsH1 LILRA3 19q13.4 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 LIR9 19q13.4 leukocyte Ig-like receptor 9 LOC390972 19 similar to pheromone receptor ILT7 19q13.4 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 4 LAIR1 19q13.4 leukocyte-associated Ig-like receptor 1 TTYH1 19q13.4 tweety homolog 1 (Drosophila) LENG8 19q13.42 leukocyte receptor cluster (LRC) member 8 LENG9 19q13.4 leukocyte receptor cluster (LRC) member 9 CDC42EP5 19q13.42 CDC42 effector protein (Rho GTPase binding) 5 LAIR2 19q13.4 leukocyte-associated Ig-like receptor 2 FLJ00060 19q13.42 hypothetical gene FLJ00060
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 2282 - 591 - -
    12 - 1982 - 491 - -
    13 - 2279 - 590 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Digestiveliver    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebonesubchondral  
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunenatural killer
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text spleen
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four extracellular Ig-like motifs
  • a single transmembrane domain
  • a cytoplasmic tail with two immunoreceptor tyrosine-based inhibitory-like motifs (ITIM), tyrosine based inhibitory motifs (ITIM), cytoplasmic immunoreceptor tyrosine-based inhibitory motifs, that down-regulate signaling by nonreceptor tyrosine kinase cascades (Tedia 2008)
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • leukocyte immunoglobulin-like receptor family
  • related to the Fc alpha receptor and natural killed inhibitory receptor superfamily
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    text expressed in mast cell granules (Tedia 2008)
    basic FUNCTION
  • playing a role in regulation of immune responses
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS