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FLASH GENE

Symbol

LILRB4

contributors: mct/ - updated : 02-04-2010

HGNC name	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
HGNC id	6608

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19q13.42      Physical location : 55.174.123 - 55.179.844
Synonym name	monocyte inhibitory receptor HM18
	immunoglobulin-like transcript 3
	leukocyte immunoglobulin-like receptor 5
	CD85 antigen-like family member K
	leukocyte immunoglobulin-like receptor subfamily B member 4 soluble isoform
Synonym symbol(s)	LIR5, LIR5-5, HM18, GP49B1H, ILT3, CD85K

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	5.73 kb     12 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map	see FLNKR@

RNA

TRANSCRIPTS	type	messenger

text	several alternatively spliced isoforms (PMID: 9151699)

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006847 12 - 2097 NP_006838 - 448 - 2009 19658091 NM_001081438 12 - 2094 NP_001074907 - 447 - 2009 19658091

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic monocyte Lymphoid/Immune B cell

cell lineage
cell lines	monocyte cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	transmembrane glycoprotein with a 73 AA signal sequence
	two Ig extracellular domains
	a long cytoplasmic tail
	three tyrosine based inhibitory motifs (ITIM), cytoplasmic immunoreceptor tyrosine-based inhibitory motifs, that down-regulate signaling by nonreceptor tyrosine kinase cascades

conjugated

GlycoP

HOMOLOGY

interspecies

ortholog to murine Gp49B-1

Homologene

FAMILY	Leucocyte Ig-like receptors (LILR) family
	subfamily B, member 4
	related to the Fc alpha receptor and natural killed inhibitory receptor superfamily

CATEGORY

receptor membrane

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	negative regulator of calcium mobilization, recruitement of SHP1, receptor internalization, and delivery of antigen into antigen processing compartments
	negatively regulate osteoclast development
	membrane and soluble forms are proteins with potent immunosuppressive activity which are of importance for treatment of rejection, autoimmunity and cancer
	potent inhibitor of monocytes activation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacting with FCGR1A (potent inhibitor of FCGR1A-mediated monocyte activation via dephosphorylation of multiple kinases)

cell & other

REGULATION

Other

developmentally regulated in mast cells

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed immunology autoimmune   its modulation may be a novel way to control various skeletal system disorders and inflammatory arthritis cancer digestive pancreas its depletion or blockade is crucial to the success of immunobiotherapy, particularly in pancreatic cancer

ANIMAL & CELL MODELS