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FLASH GENE
Symbol LILRB4 contributors: mct/ - updated : 02-04-2010
HGNC name leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
HGNC id 6608
Location 19q13.42      Physical location : 55.174.123 - 55.179.844
Synonym name
  • monocyte inhibitory receptor HM18
  • immunoglobulin-like transcript 3
  • leukocyte immunoglobulin-like receptor 5
  • CD85 antigen-like family member K
  • leukocyte immunoglobulin-like receptor subfamily B member 4 soluble isoform
  • Synonym symbol(s) LIR5, LIR5-5, HM18, GP49B1H, ILT3, CD85K
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 5.73 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map see FLNKR@
    RNA
    TRANSCRIPTS type messenger
    text several alternatively spliced isoforms (PMID: 9151699)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 2097 - 448 - 2009 19658091
    12 - 2094 - 447 - 2009 19658091
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    Lymphoid/ImmuneB cell
    cell lineage
    cell lines monocyte cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • transmembrane glycoprotein with a 73 AA signal sequence
  • two Ig extracellular domains
  • a long cytoplasmic tail
  • three tyrosine based inhibitory motifs (ITIM), cytoplasmic immunoreceptor tyrosine-based inhibitory motifs, that down-regulate signaling by nonreceptor tyrosine kinase cascades
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Gp49B-1
    Homologene
    FAMILY
  • Leucocyte Ig-like receptors (LILR) family
  • subfamily B, member 4
  • related to the Fc alpha receptor and natural killed inhibitory receptor superfamily
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • negative regulator of calcium mobilization, recruitement of SHP1, receptor internalization, and delivery of antigen into antigen processing compartments
  • negatively regulate osteoclast development
  • membrane and soluble forms are proteins with potent immunosuppressive activity which are of importance for treatment of rejection, autoimmunity and cancer
  • potent inhibitor of monocytes activation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with FCGR1A (potent inhibitor of FCGR1A-mediated monocyte activation via dephosphorylation of multiple kinases)
  • cell & other
    REGULATION
    Other developmentally regulated in mast cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyautoimmune 
    its modulation may be a novel way to control various skeletal system disorders and inflammatory arthritis
    cancerdigestivepancreas
    its depletion or blockade is crucial to the success of immunobiotherapy, particularly in pancreatic cancer
    ANIMAL & CELL MODELS