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FLASH GENE
Symbol LILRB1 contributors: mct/pgu - updated : 26-09-2013
HGNC name leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
HGNC id 6605
Location 19q13.42      Physical location : 55.128.628 - 55.149.002
Synonym name
  • CD antigen 85
  • monocyte/macrophage immunoglobulin-like receptor 7
  • immunoglobulin-like transcript 2
  • leukocyte immunoglobulin-like receptor subfamily B member 1 soluble isoform
  • CD85 antigen-like family member J
  • Ig-like transcript 2
  • Synonym symbol(s) ILT2, LIR1, LIR-1, MIR7, CD85, CD85J
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 20.38 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map see FLNKR@
    Physical map
    LILRB3 19q13.4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 ILT8 19q13.4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 6 LILRB5 19q13.4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5 LILRB2 19q13.4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 LOC390971 19 similar to YME1-like 1; ATP-dependent metalloprotease FtsH1 LILRA3 19q13.4 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 LIR9 19q13.4 leukocyte Ig-like receptor 9 LOC390972 19 similar to pheromone receptor ILT7 19q13.4 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 4 LAIR1 19q13.4 leukocyte-associated Ig-like receptor 1 TTYH1 19q13.4 tweety homolog 1 (Drosophila) LENG8 19q13.42 leukocyte receptor cluster (LRC) member 8 LENG9 19q13.4 leukocyte receptor cluster (LRC) member 9 CDC42EP5 19q13.42 CDC42 effector protein (Rho GTPase binding) 5 LAIR2 19q13.4 leukocyte-associated Ig-like receptor 2 FLJ00060 19q13.42 hypothetical gene FLJ00060 LILRB1 19q13.4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 LILRA2 19q13.4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 LILRA1 19q13.4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 LILRB4 19q13.4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 ILT9 19q13.4 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member6, pseudogene ILT10 19q13.4 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 5 KIR3DL7 19q13.42 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 5 KIR2DL3 19q13.4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3 LOC390973 19 similar to killer-cell Ig-like receptor KIR3DL7 KIR2DL1 19q13.4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 LOC390974 19 similar to 1060P11.3 (killer inhibitory receptor 2-2-2 (KIR222) (KIRX))
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 2971 110 650 - 1997 9382880
    15 - 2802 - 652 - 1997 9382880
    15 - 2859 - 651 - 1997 9382880
    15 - 2859 - 651 - 1997 9382880
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Digestiveliver    
    Nervousspinal cord    
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Lymphoid    
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    Blood/Hematopoieticmonocyte
    Lymphoid/ImmuneB cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four Ig extracellular domains
  • a long cytoplasmic tail
  • four tyrosine based inhibitory motifs (ITIM), tyrosine based inhibitory motifs (ITIM), cytoplasmic immunoreceptor tyrosine-based inhibitory motifs, that down-regulate signaling by nonreceptor tyrosine kinase cascades
  • 23 AA signal peptide
  • secondary structure
  • two Iglike domains arranged at an acute angle to form a bent structure, resembling the structures of natural killer inhibitory receptor
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • leukocyte immunoglobulin-like receptor, family (LILR family)
  • related to the Fc alpha receptor and natural killed inhibitory receptor superfamily
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • maybe playing a role in T cell activation in peripheral blood
  • negatively regulate osteoclast development
  • inhibitory receptor that binds a broad range of class I HLA molecules and is encoded by the LILRB1 gene within the leukocyte receptor complex
  • its transcription is correlated with surface protein expression on NK cells
  • important mediator of immune activation and tolerance
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to MHC class I molecule A2
  • JUND is associated with the LILRB1 distal promoter, and depletion of JUND led to a decrease in distal promoter transcript, indicating an activating role for JUNDD in regulation of LILRB1 transcription
  • cell & other
    REGULATION
    Other developmentally regulated in mast cells
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS