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FLASH GENE
Symbol LILRA3 contributors: mct - updated : 05-10-2021
HGNC name leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3
HGNC id 6604
Location 19q13.4      Physical location : 54.799.856 - 54.804.265
Synonym name
  • immunoglobulin-like transcript 6
  • leukocyte immunoglobulin-like receptor 4
  • CD85 antigen-like family member E
  • monocyte inhibitory receptor HM43/HM31
  • immunoglobulin-like transcript 6
  • Synonym symbol(s) LIR4, HM43, ILT6, HM31, CD85E, ILT-6
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 4.39 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map see FLNKR@
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1651 - 439 - 2006 16501917
    7 - 1372 - 375 - 2006 16501917
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte Homo sapiens
    Lymphoid/ImmuneB cell
    Lymphoid/Immunemacrophage
    not specificmast cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four extracellular Ig-like domains, lacking a transmembrane domain
  • HOMOLOGY
    Homologene
    FAMILY
  • leukocyte immunoglobulin-like receptor
  • subfamily A
  • Fc alpha receptor and natural killed inhibitory receptor superfamily
  • CATEGORY immunity/defense , signaling , receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    basic FUNCTION
  • acting potentially as a dominant negative soluble receptor that would suppress the function of other LIR molecules
  • LILRA3 may likely play a role in chronic inflammatory conditions such as rheumatoid arthritis
  • LILRA3 is a potential new anti-inflammatory protein, and optimal glycosylation is required for its functions
  • beneficial role for LILRA3 in virus infections, especially in ssRNA viruses, like HIV, that engage TLR8
  • LILRA3 may have a significant role in the immune pathogenesis of Severe aplastic anemia (SAA)
  • it may act as a significant function in the pathogenesis of autoimmune disorders
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in systemic lupus erythematosus (SLE) patients
    constitutional     --over  
    rheumatoid arthritis (RA)
    constitutional     --over  
    in patients with Severe aplastic anemia (SAA)
    constitutional       gain of function
    Serum LILRA3 concentrations are also significantly upregulated in patients with rheumatoid arthritis, systemic lupus erythematosus and Sjögren's syndrome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • upregulation of LILRA3 expression may serve as a biomarker of disease activity and severity of SLE
  • Therapy target
    SystemTypeDisorderPubmed
    blood  
    potential therapeutic target in Severe aplastic anemia
    ANIMAL & CELL MODELS