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FLASH GENE
Symbol LIF contributors: mct/npt - updated : 16-10-2009
HGNC name leukemia inhibitory factor (cholinergic differentiation factor)
HGNC id 6596
Location 22q12.2      Physical location : 30.636.441 - 30.642.796
Synonym name
  • D factor
  • melanoma-derived LPL inhibitor
  • cholinergic differentiation factor
  • emfilermin
  • Synonym symbol(s) CHNDT, CDF, D-FACTOR, HILDA, DIA, MLPLI
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head
    STRUCTURE 6.31 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map see TSG22A
    Physical map
    RFPL1 22q12.2 ret finger protein-like 1 NEFH 22q12.2 neurofilament, heavy polypeptide 200kDa C22orf19 22q12 chromosome 22 open reading frame 19 NIPSNAP1 22q12.2 nipsnap homolog 1 (C. elegans) NF2 22q12.2 neurofibromin 2 (bilateral acoustic neuroma) CABP7 22q12.2 calcium binding protein 7 LOC55954 22cen-q12.3 hypothetical protein LOC55954 HSPC051 22cen-q12.3 ubiquinol-cytochrome c reductase complex (7.2 kD) ASC1p100 22q12.1 ASC-1 complex subunit P100 MTMR3 22q12.2 myotubularin related protein 3 LOC391326 22 similar to h2-calponin MGC26710 22q12.2 hypothetical protein MGC26710 LIF 22q12.2 leukemia inhibitory factor (cholinergic differentiation factor) OSM 22q12.2 oncostatin M TBC1D10 22q12.1-qter TBC1 domain family, member 10 SF3A1 22q12.1 splicing factor 3a, subunit 1, 120kDa LOC388891 22 similar to hypothetical protein 4930562D19 LOC200312 22q12.2 similar to RIKEN cDNA 0610009J22 SEC14L2 22q12.2 SEC14-like 2 (S. cerevisiae) HSPC242 22q hypothetical protein HSPC242 LOC391327 22 similar to solute carrier family 39 (zinc transporter), member 1; zinc-iron regulated transporter-like gene; solute carrier family 39 (zinc transporter), member 3; zinc/iron regulated transporter-like SEC14L3 22q12.2 SEC14-like 3 (S. cerevisiae) LOC376844 SEC14L4 22q12.1 SEC14-like 4 (S. cerevisiae) PTPNS1L 22q12.2 protein tyrosine phosphatase, non-receptor type substrate 1-like CST 22q12.2 protein tyrosine phosphatase, non-receptor type substrate 1-like PES1 22q12.2 pescadillo homolog 1, containing BRCT domain (zebrafish) TCN2 22q12.2 transcobalamin II; macrocytic anemia SLC35E4 22q12.2 solute carrier family 35, member E4 LOC391328 22 similar to tum- transplantation antigen P198 DUSP18 22q12.1 dual specificity phosphatase 18 OSBP2 22q12.2 oxysterol binding protein 2 FLJ35801 22q12.2 hypothetical protein FLJ35801 ZCWCC1 22q12.2 zinc finger, CW-type with coiled-coil domain 1
    regionally located localized sistally to the breakpoint in translocation t(11;22) (q24;q12)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 3935 - 202 - Marwood (2009)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
    Endocrinepancreas   highly
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticprogenitor cell
    Lymphoid/Immunemacrophage
    Nervousastrocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • LIF/OSM (oncostatin M) family
  • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • cholinergic neuronal differentiation factor
  • inducing macrophage differentiation and in conjunction with BMP2 acting in synergy on primary fetal neural progenitor cells to induce astrocytes
  • inducing multi-lineage differentiation of adult stem-like cells in kidney via cadherin 16
  • plays a central role in the control of uterine implantation
  • reduces neurogenesis in the olfactory bulb and subventricular zone by acting directly on neural stem cells and promote neural stem cells self-renewal, preventing the emergence of more differentiated cell types
  • involved in the control of osteoclast survival and size
  • with IL11 regulated endometrial epithelial cell adhesion (Marwood 2009)
  • potential role for LIF in the melanoma-induced bone metastasis possibly through the stimulation of osteoclastogenesis (Maruta 2009)
  • inhibits osteoblast development at least in part by stimulating high molecular weight HA synthesis through HAS2 (Falconi 2007)
  • playing a role in mesenchymal stem cells mediated immunosuppression (Nasef 2008)
  • might be one of the reasons that cause patients with salpingitis to be more susceptible to tubal pregnancy and might be involved in the implantation process of tubal pregnancy (JI 2009)
  • with CNTF, LEP, IL6, participate to the complex control of the reproductive function by affecting the development and function of the hypothalamus-pituitary system at different ontogenic times and anatomical sites (Dozio 2009)
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    cell-cell singaling cooperatively with BMP2 through a complex formed by STAT3, MADH1 bridged by EP300 and the subsequent induction of astrocytes differentiation
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with HAS2 (arrests osteoblast differentiation by altering HAS2 content of the extracellular matrix) (Falconi 2007)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    higher levels of CD34, CD44, and LIF were found in the placentas of pre-eclamptic compared with normotensive women
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • may be useful, in combination with other factors, in promoting regeneration in the adult brain
  • targeting IL11 and LIF may be useful in regulating fertility by either enhancing or blocking implantation (Marwood 2009)
  • potentially effective drug target in the treatment of bone metastasis in melanoma (Maruta 2009)
  • ANIMAL & CELL MODELS