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FLASH GENE
Symbol LHX9 contributors: mct - updated : 03-10-2018
HGNC name LIM homeobox 9
HGNC id 14222
Location 1q31.3      Physical location : 197.881.634 - 197.899.273
DNA
TYPE functioning gene
STRUCTURE 22.97 kb     6 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 2515 43.84 397 - 1999 9880598
6 - 2078 42.8 388 - 1999 9880598
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveintestinelarge intestinecolon  
 intestinesmall intestine   
 liver    
Endocrineneuroendocrinepituitary    Homo sapiensFetal
 pancreas    
Reproductivefemale systemovary   
 male systemtestis   
 male systemprostate   
Respiratorylung    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two LIM zinc-binding domains
  • an homeobox domain
  • conjugated MetalloP
    HOMOLOGY
    interspecies ortholog to murine Lhx9
    Homologene
    FAMILY LIM-homeodomain gene family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in gonadal development
  • LHX2 and LHX9 determine neuronal differentiation and compartition in the caudal forebrain by regulating Wnt signaling
  • controls pineal gland development and prevents postnatal hydrocephalus
  • is a member of the LIM-homeodomain gene family necessary for the correct development of many organs including gonads, limbs, heart and the nervous system
  • LHX9 is a new molecular marker that defines a subset of amacrine cells
  • LHX9 is indispensable for testis development and testosterone production
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development , reproduction/sex
    PATHWAY
    metabolism
    signaling
  • requirement for the LHX9-integrin-paxillin pathway in proepicardial organ positioning and epicardial formation
  • a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
  • LHX9 gene represents the first direct target of the GATA4/ZFPM2 repressor complex in cardiac development
  • LHX2 binds to a conserved motif in the ROBO3 gene, suggesting that LHX2/LHX9 regulate directly the expression of ROBO3
  • LMO3 is a putative direct transcriptional target of GBX2 (GBX2 regulates the LIM transcriptional codes comprising LHX2, LHX9 and LMO3, which subsequently control the differential expression of ROBO1 and ROBO2 in the thalamus
  • GBX2 negatively regulates the transcription of LHX9 in the thalamus
  • LHX9 expression overlaps with FGF10 expression in the developing limb bud mesenchyme
  • SMURF1, an E3 ubiquitin ligase, targets LHX9 for ubiquitin-mediated proteasome degradation, thereby negatively modulating its function
  • SMURF1 promotes LHX9 ubiquitylation and is involved in testosterone production in Leydig cells directly
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS