Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

LHX9

contributors: mct - updated : 03-10-2018

HGNC name	LIM homeobox 9
HGNC id	14222

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1q31.3      Physical location : 197.881.634 - 197.899.273

DNA

TYPE	functioning gene
STRUCTURE	22.97 kb     6 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_020204 5 - 2515 NP_064589 43.84 397 - 1999 9880598 NM_001014434 6 - 2078 NP_001014434 42.8 388 - 1999 9880598

EXPRESSION

Type

widely

constitutive of

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive intestine large intestine colon       intestine small intestine         liver         Endocrine neuroendocrine pituitary       Homo sapiens Fetal   pancreas         Reproductive female system ovary         male system testis         male system prostate       Respiratory lung

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo, pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two LIM zinc-binding domains
	an homeobox domain

conjugated

MetalloP

HOMOLOGY

interspecies

ortholog to murine Lhx9

Homologene

FAMILY

LIM-homeodomain gene family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	involved in gonadal development
	LHX2 and LHX9 determine neuronal differentiation and compartition in the caudal forebrain by regulating Wnt signaling
	controls pineal gland development and prevents postnatal hydrocephalus
	is a member of the LIM-homeodomain gene family necessary for the correct development of many organs including gonads, limbs, heart and the nervous system
	LHX9 is a new molecular marker that defines a subset of amacrine cells
	LHX9 is indispensable for testis development and testosterone production

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

development , reproduction/sex

PATHWAY

metabolism

signaling

requirement for the LHX9-integrin-paxillin pathway in proepicardial organ positioning and epicardial formation

a component

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	zinc Zn2+

protein	LHX9 gene represents the first direct target of the GATA4/ZFPM2 repressor complex in cardiac development
	LHX2 binds to a conserved motif in the ROBO3 gene, suggesting that LHX2/LHX9 regulate directly the expression of ROBO3
	LMO3 is a putative direct transcriptional target of GBX2 (GBX2 regulates the LIM transcriptional codes comprising LHX2, LHX9 and LMO3, which subsequently control the differential expression of ROBO1 and ROBO2 in the thalamus
	GBX2 negatively regulates the transcription of LHX9 in the thalamus
	LHX9 expression overlaps with FGF10 expression in the developing limb bud mesenchyme
	SMURF1, an E3 ubiquitin ligase, targets LHX9 for ubiquitin-mediated proteasome degradation, thereby negatively modulating its function
	SMURF1 promotes LHX9 ubiquitylation and is involved in testosterone production in Leydig cells directly

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS