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FLASH GENE
Symbol LHX8 contributors: mct - updated : 09-07-2010
HGNC name LIM homeobox 8
HGNC id 28838
Location 1p31.1      Physical location : 75.594.118 - 75.627.216
Synonym name
  • LIM-homeodomain protein Lhx8
  • LIM homeobox protein 8
  • Synonym symbol(s) Lhx7
    DNA
    TYPE functioning gene
    STRUCTURE 33.10 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2393 - 356 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Skin/Tegumentskin    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two LIM zinc-binding domains
  • one homeodomain
  • HOMOLOGY
    interspecies homolog to rattus lhx8 (97.2pc)
    homolog to murine Lhx8 (96.6pc)
    Homologene
    FAMILY
  • LIM homeobox gene family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • having a pivotal and specific role in the development and/or maintenance of basal forebrain cholinergic neurons
  • required for the patterning or the specification and differentiation of different cell types during embryonic development
  • SOHLH1 and LHX8 are two germ cell-specific, critical regulators of oogenesis
  • transcription factor involved in differentiation of certain neurons and mesenchymal cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • zinc ions Zn2+ binding
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • candidate gene for the isolated non syndromic form of cleft palate in humans (Zhao 1999)
  • Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice with a null mutation of Lhx8 are deficient in development of forebrain cholinergic neurons (Zhao 2003)
  • in Lhx8 -/- mice, ovaries lacked germ cells and appeared histologically identical to adult Sohlh1 -/- ovaries (Pangas 2006)