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FLASH GENE
Symbol LHX5 contributors: - updated : 05-09-2007
HGNC name LIM homeobox protein 5
HGNC id 14216
Location 12q24.31-q24.32      Physical location : 113.900.693 - 113.909.877
Synonym symbol(s) MGC129689
DNA
TYPE functioning gene
STRUCTURE 9.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbraindiencephalonthalamus  
 brainhindbraincerebellum  
 brain    
 spinal cord    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain, in the developing Purkinje cells
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,chromatin/chromosome
basic FUNCTION
  • regulator of neuronal differentiation and migration during development of the central nervous system
  • playing an essential role for controlling Purkinje cell differentiation in the developing mammalian cerebellum
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    mice Lhx5-/- display severely disorganized brain,impaired cognition and motor coordination