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FLASH GENE
Symbol LHPP contributors: mct/npt - updated : 11-07-2008
Location 10q26.13      Physical location : 126.150.340 - 126.302.709
Genatlas name phospholysine phosphohistidine inorganic pyrophosphate phosphatase
Synonym name LHPP protein
Synonym symbol(s) MGC117251, MGC142189, MGC142191
EC.number 3.6.1.1
DNA
TYPE functioning gene
STRUCTURE 152.00 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
ACADSB 10q25-q26 acyl-Coenzyme A dehydrogenase, short/branched chain LOC340784 10q26.13 similar to NK-type homeobox LOC387716 10 similar to Hmx2 protein LOC387717 10 LOC387717 BUB3 10q26 BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast) LOC390009 10 similar to 40S ribosomal protein S26 GPR26 10q26.2-q26.3 G protein-coupled receptor 26 DKFZp761H2121 10q26.13 hypothetical protein DKFZp761H2121 LOC119587 10q26.13 hypothetical protein LOC119587 GALNAC4S-6ST 10q26 hypothetical protein LOC119587 FLJ12616  hypothetical protein FLJ12616 LOC340735 10q26.2 similar to germ cell specific Y-box binding protein; contrin OAT 10q26 ornithine aminotransferase (gyrate atrophy) OATL3 10q26 ornithine aminotransferase-like 3 (pseudogene) LOC390010 10 similar to Sax-1 LHPP 10q26.2 phospholysine phosphohistidine inorganic pyrophosphate phosphatase KIAA0140 10q26.2 phospholysine phosphohistidine inorganic pyrophosphate phosphatase KIAA0157 10q26.2 phospholysine phosphohistidine inorganic pyrophosphate phosphatase ZRANB1 10q26.13 zinc finger, RAN-binding domain containing 1 CTBP2 21q21.3 C-terminal binding protein 2 MRPS21P6 10q26 mitochondrial ribosomal protein S21 pseudogene 6 LOC387718 10 hypothetical gene supported by AK131010; BC062717 LOC387719 10 LOC387719 EDRF1 10q26.2 erythroid differentiation-related factor 1 MMP21 10q26.3 matrix metalloproteinase 21 UROS 10q25.2-q26.3 uroporphyrinogen III synthase (congenital erythropoietic porphyria) BCCIP 10q26.1 BRCA2 and CDKN1A interacting protein DDX32 10q26.3 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 32
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1613 - 270 - Neff (2008)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Lymphoid/Immunetonsils   highly
Nervousgangliasensory gangliadorsal root highly
Reproductivemale systemprostate  predominantly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • hydrolyzing not only oxygen-phosphorus bonds in inorganic pyrophosphate but also nitrogen-phosphorus bonds in phospholysine, phosphohistidine and imidodiphosphate
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • may interact with HTR1a in the pathogenesis of major depression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to major depression
    Variant & Polymorphism other polymorphisms increasing the major depression
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS