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FLASH GENE

Symbol

LHFPL3

contributors: mct/npt - updated : 27-04-2009

HGNC name	lipoma HMGIC fusion partner-like 3
HGNC id	6589

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	7q22.1      Physical location : 103.969.103 - 104.549.001
Synonym name	lipoma HMGIC fusion partner-like 4
	LHFP-like protein 3
Synonym symbol(s)	LHFPL4

DNA

TYPE	functioning gene
STRUCTURE	579.90 kb     3 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 3 - 3191 25.6 236 - Petit (1999)

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a polyalanine domain
	a signature sequence for the PMP22 Claudin protein family (Ptacek 2007)

HOMOLOGY

interspecies

ortholog to murine Lhfpl3 (96 pc)

Homologene

FAMILY

lipoma HMGIC fusion partner (LHFP) gene family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION

basic FUNCTION

having roles in differentiation, proliferation, and extracellular matrix formation, and implicated in tumors (Ptacek 2007)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     in uterine leiomyoma (Ptacek 2007)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS